Sex Hormones and Inflammation Role in Oral Cancer Progression: A Molecular and Biological Point of View

Oral cancers have been proven to arise from precursors lesions and to be related to risk behaviour such as alcohol consumption and smoke. However, the present paper focuses on the role of chronic inflammation, related to chronical oral infections and/or altered immune responses occurring during dysi...

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Published in:Journal of oncology 2020, Vol.2020 (2020), p.1-14
Main Authors: D’Angelo, Luigi, Inchingolo, Francesco, Feola, Antonia, Di Domenico, Marina, Coppola, Mario, Settembre, Giuliana, Sacco, Alessandra, Sciarra, Antonella, Romano, Antonio, Zannini, Giuseppa, Boccellino, Mariarosaria, Contaldo, M., Di Carlo, A.
Format: Article
Language:English
Subjects:
Angiogenesis
Cell division
Cell growth
Chemokines
Cytokines
Development and progression
Epigenetic inheritance
Growth factors
Homeostasis
Hormones
Hormones, Sex
Inflammation
Influence
Medical prognosis
Metastasis
Neutrophils
Oral cancer
Pathogens
Peptides
Prostate cancer
Review
Risk factors
Squamous cell carcinoma
Tumors
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creator D’Angelo, Luigi
Inchingolo, Francesco
Feola, Antonia
Di Domenico, Marina
Coppola, Mario
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Sacco, Alessandra
Sciarra, Antonella
Romano, Antonio
Zannini, Giuseppa
Boccellino, Mariarosaria
Contaldo, M.
Di Carlo, A.
description Oral cancers have been proven to arise from precursors lesions and to be related to risk behaviour such as alcohol consumption and smoke. However, the present paper focuses on the role of chronic inflammation, related to chronical oral infections and/or altered immune responses occurring during dysimmune and autoimmune diseases, in the oral cancerogenesis. Particularly, oral candidiasis and periodontal diseases introduce a vicious circle of nonhealing and perpetuation of the inflammatory processes, thus leading toward cancer occurrence via local and systemic inflammatory modulators and via genetic and epigenetic factors.
doi_str_mv 10.1155/2020/9587971
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source Wiley-Blackwell Open Access Collection; Publicly Available Content Database; PubMed Central
subjects Angiogenesis
Cell division
Cell growth
Chemokines
Cytokines
Development and progression
Epigenetic inheritance
Growth factors
Homeostasis
Hormones
Hormones, Sex
Inflammation
Influence
Medical prognosis
Metastasis
Neutrophils
Oral cancer
Pathogens
Peptides
Prostate cancer
Review
Risk factors
Squamous cell carcinoma
Tumors
title Sex Hormones and Inflammation Role in Oral Cancer Progression: A Molecular and Biological Point of View
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