Vitamin B12 deficiency and altered one-carbon metabolites in early pregnancy is associated with maternal obesity and dyslipidaemia

Vitamin B12 (B12) is a micronutrient essential for one-carbon (1C) metabolism. B12 deficiency disturbs the 1C cycle and alters DNA methylation which is vital for most metabolic processes. Studies show that B12 deficiency may be associated with obesity, insulin resistance and gestational diabetes; an...

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Published in:Scientific reports 2020-07, Vol.10 (1), p.11066-11066, Article 11066
Main Authors: Adaikalakoteswari, Antonysunil, Wood, Catherine, Mina, Theresia H., Webster, Craig, Goljan, Ilona, Weldeselassie, Yonas, Reynolds, Rebecca M., Saravanan, Ponnusamy
Format: Article
Language:English
Subjects:
692/699/1702
692/699/317
Adult
Anthropometry
Carbon - metabolism
Cholesterol
Cohort Studies
Diabetes mellitus
DNA methylation
Dyslipidemia
Dyslipidemias - etiology
Dyslipidemias - metabolism
Dyslipidemias - pathology
Female
Fetuses
Folic acid
High density lipoprotein
Homocysteine
Humanities and Social Sciences
Humans
Insulin
Metabolic disorders
Metabolism
Metabolites
Methionine
multidisciplinary
Obesity
Obesity, Maternal - etiology
Obesity, Maternal - metabolism
Obesity, Maternal - pathology
Offspring
Pregnancy
Pregnancy Complications - etiology
Pregnancy Complications - metabolism
Pregnancy Complications - pathology
Prognosis
Regression analysis
Science
Science (multidisciplinary)
Triglycerides
Vitamin B 12 Deficiency - complications
Vitamin B12
Vitamin deficiency
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Summary:Vitamin B12 (B12) is a micronutrient essential for one-carbon (1C) metabolism. B12 deficiency disturbs the 1C cycle and alters DNA methylation which is vital for most metabolic processes. Studies show that B12 deficiency may be associated with obesity, insulin resistance and gestational diabetes; and with obesity in child-bearing women. We therefore hypothesised that the associations between B12 deficiency, BMI and the metabolic risk could be mediated through altered 1C metabolites in early pregnancy. We explored these associations in two different early pregnancy cohorts in the UK (cohort 1; n = 244 and cohort 2; n = 60) with anthropometric data at 10–12 weeks and plasma/serum sampling at 16–18 weeks. B12, folate, total homocysteine (tHcy), methionine, MMA, metabolites of 1C metabolism (SAM, SAH) and anthropometry were measured. B12 deficiency (
ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-020-68344-0