Evaluation of Xpert MTB/RIF for the Diagnosis of Lymphatic Tuberculosis

Background. The World Health Organization approved the use of Xpert MTB/RIF for the detection of Mycobacterium tuberculosis DNA, which has significantly improved the diagnosis of tuberculosis. In this study, our main objective was to evaluate the diagnostic efficacy of Xpert MTB/RIF for lymphoid tub...

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Bibliographic Details
Published in:BioMed research international 2020, Vol.2020 (2020), p.1-11
Main Authors: Guo, Xu-Guang, Xia, Yong, Li, Zhong-Wei, Liu, Ye-Ling, Xie, Tian-Ao, Li, Gui-Lin, Liang, Jia-Qi, He, Zhi-Jian, Li, Hou-He, Feng, Xuan-Cheng
Format: Article
Language:English
Subjects:
Accuracy
Biomedical research
Deoxyribonucleic acid
Diagnosis
Diagnostic systems
Diagnostic tests
DNA
Humans
Keywords
Likelihood ratio
Microbial Sensitivity Tests
Mycobacterium tuberculosis - drug effects
Nucleic Acid Amplification Techniques - methods
Publication Bias
Quality standards
Rifampin - pharmacology
ROC Curve
Software
Statistical analysis
Tuberculosis
Tuberculosis - diagnosis
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Summary:Background. The World Health Organization approved the use of Xpert MTB/RIF for the detection of Mycobacterium tuberculosis DNA, which has significantly improved the diagnosis of tuberculosis. In this study, our main objective was to evaluate the diagnostic efficacy of Xpert MTB/RIF for lymphoid tuberculosis to determine whether Xpert MTB/RIF could be used as a routine detection method. Materials and Methods. We searched four databases for the relevant literature published from May 2007 to December 2019. The quality of the literature was evaluated with reference to the evaluation criteria. Data that were extracted from the literature on Xpert MTB/RIF diagnosis of lymphatic tuberculosis were used to plot the summary receiver operating characteristic (SROC) curve, after which the software was used to combine and analyze the accuracy of these data. Results. A total of 27 studies were included. The sensitivity of Xpert MTB/RIF for detecting lymphatic tuberculosis was 0.79 (95% CI (0.77, 0.81)), the specificity was 0.88 (95% CI (0.87, 0.90)), and the positive likelihood ratio (PLR) was 7.21 (95% CI (4.93, 10.55)). In addition, the negative likelihood ratio (NLR) was 0.25 (95% CI (0.19, 0.32)) and the diagnostic odds ratio (DOR) was 40.23 (95% CI (24.53, 65.98)). At the same time, we used the extracted data to make the SROC curve, obtaining the following parameters: area under the curve AUC=0.9144, Q=0.8470 (SE=0.0163). Conclusion. Xpert MTB/RIF has high accuracy in detecting lymphatic tuberculosis, and it can be used to quickly and easily diagnose lymphatic tuberculosis at an early stage as a general method.
ISSN:2314-6133
2314-6141
DOI:10.1155/2020/1968487