Estimation versus measurement of the glomerular filtration rate for kidney function assessment in patients with cancer undergoing cisplatin-based chemotherapy

Glomerular filtration rate (GFR) assessment is indicated before every administration of cisplatin. The optimal modality for this purpose [GFR measurement by urinary Creatinine Clearance (uCrCl) versus GFR estimation (eGFR) by the CKD-EPI formula versus both] is unclear. We investigated whether eGFR...

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Bibliographic Details
Published in:Scientific reports 2020-07, Vol.10 (1), p.11219, Article 11219
Main Authors: Klöckl, Marie-Christin, Kasparek, Anne-Katrin, Riedl, Jakob M., Moik, Florian, Mollnar, Stefanie, Stotz, Michael, Szkandera, Joanna, Terbuch, Angelika, Gerger, Armin, Niedrist, Tobias, Pichler, Martin, Bauernhofer, Thomas, Schilcher, Gernot, Zitta, Sabine, Rosenkranz, Alexander R., Friedl, Claudia, Stöger, Herbert, Posch, Florian
Format: Article
Language:English
Subjects:
692/4022/1585/4
692/4028/67/1059/99
Acute Kidney Injury - blood
Acute Kidney Injury - chemically induced
Acute Kidney Injury - diagnosis
Acute Kidney Injury - urine
Adult
Agreements
Cancer therapies
Chemotherapy
Cisplatin
Cisplatin - adverse effects
Contraindications
Creatinine
Creatinine - blood
Creatinine - metabolism
Creatinine - urine
Drug dosages
Epidemiology
Epidermal growth factor receptors
Female
Glomerular filtration rate
Glomerular Filtration Rate - drug effects
Glomerular Filtration Rate - physiology
Humanities and Social Sciences
Humans
Hydration
Internal medicine
Kidney - drug effects
Kidney - physiopathology
Kidneys
Laboratories
Male
Medicine
Middle Aged
multidisciplinary
Neoplasms - blood
Neoplasms - drug therapy
Neoplasms - urine
Patients
Qualitative analysis
Renal Elimination - physiology
Retrospective Studies
Science
Science (multidisciplinary)
Sensitivity analysis
Urine
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Description
Summary:Glomerular filtration rate (GFR) assessment is indicated before every administration of cisplatin. The optimal modality for this purpose [GFR measurement by urinary Creatinine Clearance (uCrCl) versus GFR estimation (eGFR) by the CKD-EPI formula versus both] is unclear. We investigated whether eGFR only is safe in this setting. Paired uCrCl and eGFR determinations from 470 cisplatin cycles from 121 patients were analyzed [median age: 55 years; most frequent tumor site: genitourinary (45%); palliative treatment: n = 41 (34%)]. Primary endpoint was the proportion of cycles with uCrCl 
ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-020-68010-5