Leveraging a Landmark Trial of Primary Cardiovascular Disease Prevention in Human Immunodeficiency Virus: Introduction From the REPRIEVE Coprincipal Investigators

• Published in: The Journal of infectious diseases 2020-07, Vol.222 (Supplement_1), p.S1-S7
• Main Authors: Grinspoon, Steven K, Douglas, Pamela S, Hoffmann, Udo, Ribaudo, Heather J
• Format: Article
• Language: English
• Subjects: Aged; Anti-Retroviral Agents - therapeutic use; Antiretroviral therapy; Cardiovascular disease; Cardiovascular diseases; Cardiovascular Diseases - complications; Cardiovascular Diseases - drug therapy; Cardiovascular Diseases - prevention & control; Comorbidity; Disease prevention; Female; Global Burden of Disease; HIV; HIV Infections - complications; HIV Infections - drug therapy; Human immunodeficiency virus; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors - therapeutic use; Immune response; Immune system; Male; Middle Aged; Phenotyping; Primary Prevention; Randomized Controlled Trials as Topic; Renal function; Research Subjects; Steatosis; Supplement
• ISSN: 0022-1899; 1537-6613
• DOI: 10.1093/infdis/jiaa098

Abstract The Randomized Trial to Prevent Vascular Events in HIV (REPRIEVE) is the largest study of cardiovascular disease in human immunodeficiency virus. Enrolling 7770 participants from 2015 to 2019 with sites across 5 continents, REPRIEVE will assess the effects of a statin as a cardiovascular disease prevention strategy in people with HIV (PWH) receiving antiretroviral therapy (ART). Although the primary purpose of REPRIEVE, and its substudy assessing coronary plaque, is to assess cardiovascular outcomes, the trial is a rich source of data on population characteristics and critical comorbidities in PWH, particularly across Global Burden of Disease (GBD) regions, reflective of the ethnic, racial, and gender diversity in this global epidemic. The purpose of this Supplement is to leverage the rich phenotyping in REPRIEVE, to provide data on detailed patterns of baseline ART and immune function by GBD region, reproductive aging among cisgender women, and data on the participation and clinical characteristics of transgender participants. We also leveraged REPRIEVE to assess critical comorbidities, including renal dysfunction, muscle function and frailty, and myocardial steatosis. REPRIEVE is a remarkable collaboration between funders, trial networks, clinical research sites, clinical and data coordinating centers, and willing participants who devoted their time to make the trial possible.