MeCP2 inhibits proliferation and migration of breast cancer via suppression of epithelial‐mesenchymal transition

Methyl‐CpG‐binding protein 2 (MeCP2) is an important epigenetic regulator for normal neuronal maturation and brain glial cell function. Additionally, MeCP2 is also involved in a variety of cancers, such as breast, prostate, lung, liver and colorectal. However, whether MeCP2 contributes to the progre...

Full description

Saved in:
Bibliographic Details
Published in:Journal of cellular and molecular medicine 2020-07, Vol.24 (14), p.7959-7967
Main Authors: Jiang, Wei, Liang, Yan‐Ling, Liu, Yang, Chen, Yu‐Yan, Yang, Shu‐Ting, Li, Bi‐Rong, Yu, Ying‐Xian, Lyu, Yansi, Wang, Rikang
Format: Article
Language:English
Subjects:
Antibodies
Binding sites
Breast cancer
Breast Neoplasms - genetics
Breast Neoplasms - metabolism
Breast Neoplasms - pathology
Cell Line, Tumor
Cell migration
Cell Movement - genetics
Cell Proliferation
Cell Survival - genetics
Deoxyribonucleic acid
DNA
DNA methylation
Epithelial-Mesenchymal Transition - genetics
epithelial‐mesenchymal transition (EMT)
Female
Gene Expression Regulation, Neoplastic
Gene Knockdown Techniques
Glial cells
Humans
Immunohistochemistry
invasion
MeCP2 protein
Mesenchyme
Metastasis
Methyl-CpG binding protein
Methyl-CpG-Binding Protein 2 - genetics
Methyl-CpG-Binding Protein 2 - metabolism
Methyl‐CpG‐binding protein 2 (MeCP2)
Neuronal-glial interactions
Original
Prostate
Proteins
Tumor cell lines
Tumors
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Methyl‐CpG‐binding protein 2 (MeCP2) is an important epigenetic regulator for normal neuronal maturation and brain glial cell function. Additionally, MeCP2 is also involved in a variety of cancers, such as breast, prostate, lung, liver and colorectal. However, whether MeCP2 contributes to the progression of breast cancer remains unknown. In the present study, we investigated the role of MeCP2 in cell proliferation, migration and invasion in vitro. We found that knockdown of MeCP2 inhibited expression of epithelial‐mesenchymal transition (EMT)‐related markers in breast cancer cell lines. In conclusion, our study suggests that MeCP2 inhibits proliferation and invasion through suppression of the EMT pathway in breast cancer.
ISSN:1582-1838
1582-4934
DOI:10.1111/jcmm.15428