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Infectivity, virulence, pathogenicity, host-pathogen interactions of SARS and SARS-CoV-2 in experimental animals: a systematic review
The outbreak of the SARS-CoV-2 in mainland China with subsequent human to human transmission worldwide had taken up the shape of a devastating pandemic. The ability of the virus to infect multiple species other than humans has currently been reported in experimental conditions. Non-human primates, f...
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| Published in: | Veterinary research communications 2020-11, Vol.44 (3-4), p.101-110 |
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| creator | Sarkar, Jayanta Guha, Rajdeep |
| description | The outbreak of the SARS-CoV-2 in mainland China with subsequent human to human transmission worldwide had taken up the shape of a devastating pandemic. The ability of the virus to infect multiple species other than humans has currently been reported in experimental conditions. Non-human primates, felines, ferrets, rodents and host of other animals could previously be infected in experimental conditions with SARS-CoV and recently with SARS-CoV-2, both virus using Angiotensin-converting-enzyme 2 receptor for cellular entry. The variations in sequence homology of ACE2 receptor across species is identified as one of the factors determining virulence and pathogenicity in animals. The infection in experimental animals with SARS-CoV or SARS-CoV-2 on most occasions are asymptomatic, however, the virus could multiply within the respiratory tract and extra-pulmonary organs in most of the species. Here, we discuss about the pathogenicity, transmission, variations in angiotensin-converting-enzyme 2 receptor-binding across species and host pathogen interactions of SARS and SARS-CoV-2 in laboratory animals used in research. |
| doi_str_mv | 10.1007/s11259-020-09778-9 |
| format | article |
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| source | Springer Nature |
| subjects | Animals Betacoronavirus - pathogenicity Biomedical and Life Sciences Callithrix - virology Cats - virology Chickens - virology Chiroptera - virology Chlorocebus aethiops - virology Coronavirus Infections - transmission Coronavirus Infections - veterinary Coronavirus Infections - virology COVID-19 Cricetinae - virology Ferrets - virology Host-Pathogen Interactions Life Sciences Macaca fascicularis - virology Macaca mulatta - virology Mice Mice, Inbred Strains - virology Pandemics - veterinary Pneumonia, Viral - transmission Pneumonia, Viral - veterinary Pneumonia, Viral - virology Review Review Article Rodentia - virology SARS Virus - pathogenicity SARS-CoV-2 Severe Acute Respiratory Syndrome - transmission Severe Acute Respiratory Syndrome - veterinary Severe Acute Respiratory Syndrome - virology Swine - virology Veterinary Medicine/Veterinary Science Zoology |
| title | Infectivity, virulence, pathogenicity, host-pathogen interactions of SARS and SARS-CoV-2 in experimental animals: a systematic review |
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