Coat Color Roan Shows Association with KIT Variants and No Evidence of Lethality in Icelandic Horses

Roan (Rn) horses show a typical seasonal change of color. Their body is covered with colored and white hair. We performed a descriptive statistical analysis of breeding records of Icelandic horses to challenge the hypothesis of roan being lethal in utero under homozygous condition. The roan to non-r...

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Bibliographic Details
Published in:Genes 2020-06, Vol.11 (6), p.680
Main Authors: Voß, Katharina, Tetens, Julia, Thaller, Georg, Becker, Doreen
Format: Article
Language:English
Subjects:
Animals
Breeding
Brief Report
Cell growth
Chromosomes
Color
Coloration
Epistasis
Genes, Lethal - genetics
Genotype & phenotype
Growth factors
Hair
Hair Color - genetics
Horse Diseases - genetics
Horse Diseases - pathology
Horses
Horses - genetics
Hypotheses
KIT protein
Lethality
Mutation
Mutation - genetics
Phenotype
Phenotypes
Proteins
Proto-Oncogene Proteins c-kit - genetics
Seasonal variations
Statistical analysis
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Summary:Roan (Rn) horses show a typical seasonal change of color. Their body is covered with colored and white hair. We performed a descriptive statistical analysis of breeding records of Icelandic horses to challenge the hypothesis of roan being lethal in utero under homozygous condition. The roan to non-roan ratio of foals from roan × roan matings revealed homozygous roan Icelandic horses to be viable. Even though roan is known to be inherited in a dominant mode and epistatic to other coat colors, the causative mutation is still unknown. Nevertheless, an association between roan phenotype and the gene was shown for different horse breeds. In the present study, we identified variants by Sanger sequencing, and show that is also associated with roan in the Icelandic horse breed.
ISSN:2073-4425
2073-4425
DOI:10.3390/genes11060680