Distinct Local and Systemic Molecular Signatures in the Esophageal and Gastric Cancers: Possible Therapy Targets and Biomarkers for Gastric Cancer

• Published in: International journal of molecular sciences 2020-06, Vol.21 (12), p.4509
• Main Authors: Bednarz-Misa, Iwona, Fortuna, Paulina, Diakowska, Dorota, Jamrozik, Natalia, Krzystek-Korpacka, Małgorzata
• Format: Article
• Language: English
• Subjects: Abnormalities; Aged; Angiogenesis; Biomarkers; Biomarkers, Tumor - genetics; Cancer therapies; Cell cycle; Cell Line, Tumor; Chemokine CCL5 - genetics; Chemokines; Chemotherapy; Cytokines; Cytokines - genetics; Esophageal cancer; Esophageal Neoplasms - genetics; Esophageal Neoplasms - metabolism; Esophagus; Female; Fibroblast growth factor 2; Gastric cancer; Gene expression; Gene Expression - genetics; Gene Expression Profiling - methods; Granulocytes; Growth factors; Heart; Humans; IL-1β; Inflammation; Interleukin 1; Interleukin 1 receptor antagonist; Interleukin 1 receptors; Interleukin 10; Interleukin 13; Interleukin 4; Interleukin 6; Interleukin 9; Interleukin-1beta - genetics; Interleukin-6 - genetics; Male; Metabolism; Middle Aged; Monocyte chemoattractant protein 1; Neoplasm Recurrence, Local - genetics; Polymerase chain reaction; Proteins; RANTES; Stomach Neoplasms - genetics; Stomach Neoplasms - metabolism; Stomach Neoplasms - pathology; Therapeutic applications; Transcriptome - genetics; Tumors; Vascular endothelial growth factor
• ISSN: 1422-0067; 1661-6596; 1422-0067
• DOI: 10.3390/ijms21124509

Gastric (GC) and esophageal (EC) cancers are highly lethal. Better understanding of molecular abnormalities is needed for new therapeutic targets and biomarkers to be found. Expression of 18 cancer-related genes in 31 paired normal-tumor samples was quantified by reversely-transcribed quantitative polymerase chain reaction (RTqPCR) and systemic concentration of 27 cytokines/chemokines/growth factors in 195 individuals was determined using Luminex xMAP technology. Only , and were altered in GC while , , , , , , , , , , and were changed in EC. The relatively unaltered molecular GC landscape resulted from high expression of , , , , , , , , , , , , and in non-cancerous tissue. The expression and IL-4, IL-9, FGF2, and RANTES secretion were higher in cardiac than non-cardiac GC. Four-cytokine panels (interleukin (IL)-1β/IL-1ra/IL-6/RANTES or IL-1β/IL-6/IL-4/IL-13) differentiated GC from benign conditions with 87-89% accuracy. Our results showed increased proliferative, survival, inflammatory and angiogenic capacity in gastric tumor-surrounding tissue, what might contribute to GC aggressiveness and facilitate cancer recurrence. Further studies are needed to determine the and suitability as candidate molecular targets in GC and cardiac GC, respectively, and discern the role of or to verify IL-1β/IL-1ra/IL-6/RANTES or IL-1β/IL-6/IL-4/IL-13 usefulness as differential biomarkers.