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Distinct Local and Systemic Molecular Signatures in the Esophageal and Gastric Cancers: Possible Therapy Targets and Biomarkers for Gastric Cancer
Gastric (GC) and esophageal (EC) cancers are highly lethal. Better understanding of molecular abnormalities is needed for new therapeutic targets and biomarkers to be found. Expression of 18 cancer-related genes in 31 paired normal-tumor samples was quantified by reversely-transcribed quantitative p...
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| Published in: | International journal of molecular sciences 2020-06, Vol.21 (12), p.4509 |
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| creator | Bednarz-Misa, Iwona Fortuna, Paulina Diakowska, Dorota Jamrozik, Natalia Krzystek-Korpacka, Małgorzata |
| description | Gastric (GC) and esophageal (EC) cancers are highly lethal. Better understanding of molecular abnormalities is needed for new therapeutic targets and biomarkers to be found. Expression of 18 cancer-related genes in 31 paired normal-tumor samples was quantified by reversely-transcribed quantitative polymerase chain reaction (RTqPCR) and systemic concentration of 27 cytokines/chemokines/growth factors in 195 individuals was determined using Luminex xMAP technology. Only
,
and
were altered in GC while
,
,
,
,
,
,
,
,
,
,
and
were changed in EC. The relatively unaltered molecular GC landscape resulted from high expression of
,
,
,
,
,
,
,
,
,
,
,
, and
in non-cancerous tissue. The
expression and IL-4, IL-9, FGF2, and RANTES secretion were higher in cardiac than non-cardiac GC. Four-cytokine panels (interleukin (IL)-1β/IL-1ra/IL-6/RANTES or IL-1β/IL-6/IL-4/IL-13) differentiated GC from benign conditions with 87-89% accuracy. Our results showed increased proliferative, survival, inflammatory and angiogenic capacity in gastric tumor-surrounding tissue, what might contribute to GC aggressiveness and facilitate cancer recurrence. Further studies are needed to determine the
and
suitability as candidate molecular targets in GC and cardiac GC, respectively, and discern the role of
or to verify IL-1β/IL-1ra/IL-6/RANTES or IL-1β/IL-6/IL-4/IL-13 usefulness as differential biomarkers. |
| doi_str_mv | 10.3390/ijms21124509 |
| format | article |
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,
and
were altered in GC while
,
,
,
,
,
,
,
,
,
,
and
were changed in EC. The relatively unaltered molecular GC landscape resulted from high expression of
,
,
,
,
,
,
,
,
,
,
,
, and
in non-cancerous tissue. The
expression and IL-4, IL-9, FGF2, and RANTES secretion were higher in cardiac than non-cardiac GC. Four-cytokine panels (interleukin (IL)-1β/IL-1ra/IL-6/RANTES or IL-1β/IL-6/IL-4/IL-13) differentiated GC from benign conditions with 87-89% accuracy. Our results showed increased proliferative, survival, inflammatory and angiogenic capacity in gastric tumor-surrounding tissue, what might contribute to GC aggressiveness and facilitate cancer recurrence. Further studies are needed to determine the
and
suitability as candidate molecular targets in GC and cardiac GC, respectively, and discern the role of
or to verify IL-1β/IL-1ra/IL-6/RANTES or IL-1β/IL-6/IL-4/IL-13 usefulness as differential biomarkers.</description><identifier>ISSN: 1422-0067</identifier><identifier>ISSN: 1661-6596</identifier><identifier>EISSN: 1422-0067</identifier><identifier>DOI: 10.3390/ijms21124509</identifier><identifier>PMID: 32630408</identifier><language>eng</language><publisher>Switzerland: MDPI AG</publisher><subject>Abnormalities ; Aged ; Angiogenesis ; Biomarkers ; Biomarkers, Tumor - genetics ; Cancer therapies ; Cell cycle ; Cell Line, Tumor ; Chemokine CCL5 - genetics ; Chemokines ; Chemotherapy ; Cytokines ; Cytokines - genetics ; Esophageal cancer ; Esophageal Neoplasms - genetics ; Esophageal Neoplasms - metabolism ; Esophagus ; Female ; Fibroblast growth factor 2 ; Gastric cancer ; Gene expression ; Gene Expression - genetics ; Gene Expression Profiling - methods ; Granulocytes ; Growth factors ; Heart ; Humans ; IL-1β ; Inflammation ; Interleukin 1 ; Interleukin 1 receptor antagonist ; Interleukin 1 receptors ; Interleukin 10 ; Interleukin 13 ; Interleukin 4 ; Interleukin 6 ; Interleukin 9 ; Interleukin-1beta - genetics ; Interleukin-6 - genetics ; Male ; Metabolism ; Middle Aged ; Monocyte chemoattractant protein 1 ; Neoplasm Recurrence, Local - genetics ; Polymerase chain reaction ; Proteins ; RANTES ; Stomach Neoplasms - genetics ; Stomach Neoplasms - metabolism ; Stomach Neoplasms - pathology ; Therapeutic applications ; Transcriptome - genetics ; Tumors ; Vascular endothelial growth factor</subject><ispartof>International journal of molecular sciences, 2020-06, Vol.21 (12), p.4509</ispartof><rights>2020. This work is licensed under http://creativecommons.org/licenses/by/3.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2020 by the authors. 2020</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c478t-f48fe5a088953a757ae840db3a8c372f25d0f8d19d810ab1573c4e57fae211ce3</citedby><cites>FETCH-LOGICAL-c478t-f48fe5a088953a757ae840db3a8c372f25d0f8d19d810ab1573c4e57fae211ce3</cites><orcidid>0000-0001-7244-2017 ; 0000-0002-2753-8092 ; 0000-0003-4617-798X ; 0000-0002-1377-5601 ; 0000-0002-0478-0038</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.proquest.com/docview/2418884497/fulltextPDF?pq-origsite=primo$$EPDF$$P50$$Gproquest$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.proquest.com/docview/2418884497?pq-origsite=primo$$EHTML$$P50$$Gproquest$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,25731,27901,27902,36989,36990,44566,53766,53768,74869</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32630408$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Bednarz-Misa, Iwona</creatorcontrib><creatorcontrib>Fortuna, Paulina</creatorcontrib><creatorcontrib>Diakowska, Dorota</creatorcontrib><creatorcontrib>Jamrozik, Natalia</creatorcontrib><creatorcontrib>Krzystek-Korpacka, Małgorzata</creatorcontrib><title>Distinct Local and Systemic Molecular Signatures in the Esophageal and Gastric Cancers: Possible Therapy Targets and Biomarkers for Gastric Cancer</title><title>International journal of molecular sciences</title><addtitle>Int J Mol Sci</addtitle><description>Gastric (GC) and esophageal (EC) cancers are highly lethal. Better understanding of molecular abnormalities is needed for new therapeutic targets and biomarkers to be found. Expression of 18 cancer-related genes in 31 paired normal-tumor samples was quantified by reversely-transcribed quantitative polymerase chain reaction (RTqPCR) and systemic concentration of 27 cytokines/chemokines/growth factors in 195 individuals was determined using Luminex xMAP technology. Only
,
and
were altered in GC while
,
,
,
,
,
,
,
,
,
,
and
were changed in EC. The relatively unaltered molecular GC landscape resulted from high expression of
,
,
,
,
,
,
,
,
,
,
,
, and
in non-cancerous tissue. The
expression and IL-4, IL-9, FGF2, and RANTES secretion were higher in cardiac than non-cardiac GC. Four-cytokine panels (interleukin (IL)-1β/IL-1ra/IL-6/RANTES or IL-1β/IL-6/IL-4/IL-13) differentiated GC from benign conditions with 87-89% accuracy. Our results showed increased proliferative, survival, inflammatory and angiogenic capacity in gastric tumor-surrounding tissue, what might contribute to GC aggressiveness and facilitate cancer recurrence. Further studies are needed to determine the
and
suitability as candidate molecular targets in GC and cardiac GC, respectively, and discern the role of
or to verify IL-1β/IL-1ra/IL-6/RANTES or IL-1β/IL-6/IL-4/IL-13 usefulness as differential biomarkers.</description><subject>Abnormalities</subject><subject>Aged</subject><subject>Angiogenesis</subject><subject>Biomarkers</subject><subject>Biomarkers, Tumor - genetics</subject><subject>Cancer therapies</subject><subject>Cell cycle</subject><subject>Cell Line, Tumor</subject><subject>Chemokine CCL5 - genetics</subject><subject>Chemokines</subject><subject>Chemotherapy</subject><subject>Cytokines</subject><subject>Cytokines - genetics</subject><subject>Esophageal cancer</subject><subject>Esophageal Neoplasms - genetics</subject><subject>Esophageal Neoplasms - metabolism</subject><subject>Esophagus</subject><subject>Female</subject><subject>Fibroblast growth factor 2</subject><subject>Gastric cancer</subject><subject>Gene expression</subject><subject>Gene Expression - genetics</subject><subject>Gene Expression Profiling - methods</subject><subject>Granulocytes</subject><subject>Growth factors</subject><subject>Heart</subject><subject>Humans</subject><subject>IL-1β</subject><subject>Inflammation</subject><subject>Interleukin 1</subject><subject>Interleukin 1 receptor antagonist</subject><subject>Interleukin 1 receptors</subject><subject>Interleukin 10</subject><subject>Interleukin 13</subject><subject>Interleukin 4</subject><subject>Interleukin 6</subject><subject>Interleukin 9</subject><subject>Interleukin-1beta - genetics</subject><subject>Interleukin-6 - genetics</subject><subject>Male</subject><subject>Metabolism</subject><subject>Middle Aged</subject><subject>Monocyte chemoattractant protein 1</subject><subject>Neoplasm Recurrence, Local - genetics</subject><subject>Polymerase chain reaction</subject><subject>Proteins</subject><subject>RANTES</subject><subject>Stomach Neoplasms - genetics</subject><subject>Stomach Neoplasms - metabolism</subject><subject>Stomach Neoplasms - pathology</subject><subject>Therapeutic applications</subject><subject>Transcriptome - genetics</subject><subject>Tumors</subject><subject>Vascular endothelial growth factor</subject><issn>1422-0067</issn><issn>1661-6596</issn><issn>1422-0067</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>PIMPY</sourceid><recordid>eNpdkUtvEzEUhS0EoqWwY40ssWFBwK-pPSwqQSgFKQikhrV147mTOMzYwfYg5W_wizE0VKErX8nfOfdxCHnK2SspW_bab8csOBeqYe09csqVEDPGzvX9o_qEPMp5y5iQomkfkhMpziVTzJySX-99Lj64QhfRwUAhdPR6nwuO3tHPcUA3DZDotV8HKFPCTH2gZYP0MsfdBtZ40FxBLqlK5hAcpvyGfo05-9WAdLnBBLs9XUJaY8l_6Xc-jpC-V5D2Md0RPyYPehgyPjm8Z-Tbh8vl_ONs8eXq0_ztYuaUNmXWK9NjA8yYtpGgGw1oFOtWEoyTWvSi6VhvOt52hjNY8UZLp7DRPWA9l0N5Ri5ufHfTasTOYSgJBrtLvs62txG8_f8n-I1dx59WS9W2QlSDFweDFH9MmIsdfXY4DBAwTtkKVRtxXdmKPr-DbuOUQl2vUtwYo1SrK_XyhnKpXi9hfzsMZ_ZP2PY47Io_O17gFv6XrvwNfnyn-A</recordid><startdate>20200625</startdate><enddate>20200625</enddate><creator>Bednarz-Misa, Iwona</creator><creator>Fortuna, Paulina</creator><creator>Diakowska, Dorota</creator><creator>Jamrozik, Natalia</creator><creator>Krzystek-Korpacka, Małgorzata</creator><general>MDPI AG</general><general>MDPI</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>MBDVC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0001-7244-2017</orcidid><orcidid>https://orcid.org/0000-0002-2753-8092</orcidid><orcidid>https://orcid.org/0000-0003-4617-798X</orcidid><orcidid>https://orcid.org/0000-0002-1377-5601</orcidid><orcidid>https://orcid.org/0000-0002-0478-0038</orcidid></search><sort><creationdate>20200625</creationdate><title>Distinct Local and Systemic Molecular Signatures in the Esophageal and Gastric Cancers: Possible Therapy Targets and Biomarkers for Gastric Cancer</title><author>Bednarz-Misa, Iwona ; Fortuna, Paulina ; Diakowska, Dorota ; Jamrozik, Natalia ; Krzystek-Korpacka, Małgorzata</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c478t-f48fe5a088953a757ae840db3a8c372f25d0f8d19d810ab1573c4e57fae211ce3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Abnormalities</topic><topic>Aged</topic><topic>Angiogenesis</topic><topic>Biomarkers</topic><topic>Biomarkers, Tumor - genetics</topic><topic>Cancer therapies</topic><topic>Cell cycle</topic><topic>Cell Line, Tumor</topic><topic>Chemokine CCL5 - genetics</topic><topic>Chemokines</topic><topic>Chemotherapy</topic><topic>Cytokines</topic><topic>Cytokines - genetics</topic><topic>Esophageal cancer</topic><topic>Esophageal Neoplasms - genetics</topic><topic>Esophageal Neoplasms - metabolism</topic><topic>Esophagus</topic><topic>Female</topic><topic>Fibroblast growth factor 2</topic><topic>Gastric cancer</topic><topic>Gene expression</topic><topic>Gene Expression - genetics</topic><topic>Gene Expression Profiling - methods</topic><topic>Granulocytes</topic><topic>Growth factors</topic><topic>Heart</topic><topic>Humans</topic><topic>IL-1β</topic><topic>Inflammation</topic><topic>Interleukin 1</topic><topic>Interleukin 1 receptor antagonist</topic><topic>Interleukin 1 receptors</topic><topic>Interleukin 10</topic><topic>Interleukin 13</topic><topic>Interleukin 4</topic><topic>Interleukin 6</topic><topic>Interleukin 9</topic><topic>Interleukin-1beta - genetics</topic><topic>Interleukin-6 - genetics</topic><topic>Male</topic><topic>Metabolism</topic><topic>Middle Aged</topic><topic>Monocyte chemoattractant protein 1</topic><topic>Neoplasm Recurrence, Local - genetics</topic><topic>Polymerase chain reaction</topic><topic>Proteins</topic><topic>RANTES</topic><topic>Stomach Neoplasms - genetics</topic><topic>Stomach Neoplasms - metabolism</topic><topic>Stomach Neoplasms - pathology</topic><topic>Therapeutic applications</topic><topic>Transcriptome - genetics</topic><topic>Tumors</topic><topic>Vascular endothelial growth factor</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Bednarz-Misa, Iwona</creatorcontrib><creatorcontrib>Fortuna, Paulina</creatorcontrib><creatorcontrib>Diakowska, Dorota</creatorcontrib><creatorcontrib>Jamrozik, Natalia</creatorcontrib><creatorcontrib>Krzystek-Korpacka, Małgorzata</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>ProQuest - 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>International journal of molecular sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Bednarz-Misa, Iwona</au><au>Fortuna, Paulina</au><au>Diakowska, Dorota</au><au>Jamrozik, Natalia</au><au>Krzystek-Korpacka, Małgorzata</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Distinct Local and Systemic Molecular Signatures in the Esophageal and Gastric Cancers: Possible Therapy Targets and Biomarkers for Gastric Cancer</atitle><jtitle>International journal of molecular sciences</jtitle><addtitle>Int J Mol Sci</addtitle><date>2020-06-25</date><risdate>2020</risdate><volume>21</volume><issue>12</issue><spage>4509</spage><pages>4509-</pages><issn>1422-0067</issn><issn>1661-6596</issn><eissn>1422-0067</eissn><abstract>Gastric (GC) and esophageal (EC) cancers are highly lethal. Better understanding of molecular abnormalities is needed for new therapeutic targets and biomarkers to be found. Expression of 18 cancer-related genes in 31 paired normal-tumor samples was quantified by reversely-transcribed quantitative polymerase chain reaction (RTqPCR) and systemic concentration of 27 cytokines/chemokines/growth factors in 195 individuals was determined using Luminex xMAP technology. Only
,
and
were altered in GC while
,
,
,
,
,
,
,
,
,
,
and
were changed in EC. The relatively unaltered molecular GC landscape resulted from high expression of
,
,
,
,
,
,
,
,
,
,
,
, and
in non-cancerous tissue. The
expression and IL-4, IL-9, FGF2, and RANTES secretion were higher in cardiac than non-cardiac GC. Four-cytokine panels (interleukin (IL)-1β/IL-1ra/IL-6/RANTES or IL-1β/IL-6/IL-4/IL-13) differentiated GC from benign conditions with 87-89% accuracy. Our results showed increased proliferative, survival, inflammatory and angiogenic capacity in gastric tumor-surrounding tissue, what might contribute to GC aggressiveness and facilitate cancer recurrence. Further studies are needed to determine the
and
suitability as candidate molecular targets in GC and cardiac GC, respectively, and discern the role of
or to verify IL-1β/IL-1ra/IL-6/RANTES or IL-1β/IL-6/IL-4/IL-13 usefulness as differential biomarkers.</abstract><cop>Switzerland</cop><pub>MDPI AG</pub><pmid>32630408</pmid><doi>10.3390/ijms21124509</doi><orcidid>https://orcid.org/0000-0001-7244-2017</orcidid><orcidid>https://orcid.org/0000-0002-2753-8092</orcidid><orcidid>https://orcid.org/0000-0003-4617-798X</orcidid><orcidid>https://orcid.org/0000-0002-1377-5601</orcidid><orcidid>https://orcid.org/0000-0002-0478-0038</orcidid><oa>free_for_read</oa></addata></record> |
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| language | eng |
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| subjects | Abnormalities Aged Angiogenesis Biomarkers Biomarkers, Tumor - genetics Cancer therapies Cell cycle Cell Line, Tumor Chemokine CCL5 - genetics Chemokines Chemotherapy Cytokines Cytokines - genetics Esophageal cancer Esophageal Neoplasms - genetics Esophageal Neoplasms - metabolism Esophagus Female Fibroblast growth factor 2 Gastric cancer Gene expression Gene Expression - genetics Gene Expression Profiling - methods Granulocytes Growth factors Heart Humans IL-1β Inflammation Interleukin 1 Interleukin 1 receptor antagonist Interleukin 1 receptors Interleukin 10 Interleukin 13 Interleukin 4 Interleukin 6 Interleukin 9 Interleukin-1beta - genetics Interleukin-6 - genetics Male Metabolism Middle Aged Monocyte chemoattractant protein 1 Neoplasm Recurrence, Local - genetics Polymerase chain reaction Proteins RANTES Stomach Neoplasms - genetics Stomach Neoplasms - metabolism Stomach Neoplasms - pathology Therapeutic applications Transcriptome - genetics Tumors Vascular endothelial growth factor |
| title | Distinct Local and Systemic Molecular Signatures in the Esophageal and Gastric Cancers: Possible Therapy Targets and Biomarkers for Gastric Cancer |
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