Further Evidence of Benefits to Mood and Working Memory from Lipidated Curcumin in Healthy Older People: A 12-Week, Double-Blind, Placebo-Controlled, Partial Replication Study

• Published in: Nutrients 2020-06, Vol.12 (6), p.1678
• Main Authors: Cox, Katherine H M, White, David J, Pipingas, Andrew, Poorun, Kaylass, Scholey, Andrew
• Format: Article
• Language: English
• Subjects: Affect - drug effects; Age; Aged; Aged, 80 and over; Aging; Bioavailability; Biomarkers; Clinical trials; Cognition; Cognition & reasoning; Cognition - drug effects; Cognitive ability; Cognitive Aging; Cognitive Dysfunction - prevention & control; Curcumin; Curcumin - administration & dosage; Curcumin - pharmacology; Dementia; Diabetes; Dietary Supplements; Double-Blind Method; Double-blind studies; Drug dosages; Fatigue; Fatigue - prevention & control; Female; Flavonoids; Food; Healthy Aging - psychology; Hippocampus; Humans; Hyperglycemia; Male; Memory; Memory, Short-Term - drug effects; Middle Aged; Mood; Older people; Replication; Short term memory; Treatment Outcome; Tumor necrosis factor-TNF
• ISSN: 2072-6643; 2072-6643
• DOI: 10.3390/nu12061678

Curcumin (a flavonoid isolated from turmeric) affects several processes involved in neurocognitive aging. We have previously reported that short term (4-weeks) administration of a highly bioavailable curcumin preparation (Longvida©) improved working memory and reduced fatigue and stress reactivity in a healthy older cohort. The present trial (ACTRN12616000484448) was a partial replication study, evaluating similar effects at 4 and 12-weeks Longvida© supplementation. A double-blind, placebo-controlled, parallel-groups trial was conducted. Eighty participants aged 50-80 years (mean = 68.1, SD = 6.34) were randomised to receive Longvida© (400 mg daily containing 80 mg curcumin) or a matching placebo. Assessment took place at baseline then following 4 and 12 weeks treatment. Outcome measures included cognitive performance, mood and biomarkers. Compared with placebo, curcumin was associated with several significant effects. These included better working memory performance at 12-weeks (Serial Threes, Serial Sevens and performance on a virtual Morris Water Maze), and lower fatigue scores on the Profile of Mood States (POMS) at both 4 and 12-weeks, and of tension, anger, confusion and total mood disturbance at 4-weeks only. The curcumin group had significantly elevated blood glucose. These results confirm that Longvida© improves aspects of mood and working memory in a healthy older cohort. The pattern of results is consistent with improvements in hippocampal function and may hold promise for alleviating cognitive decline in some populations.