Current Perspectives on 89Zr-PET Imaging

89Zr is an emerging radionuclide that plays an essential role in immuno-positron emission tomography (PET) imaging. The long half-life of 89Zr (t1/2 = 3.3 days) is favorable for evaluating the in vivo distribution of monoclonal antibodies. Thus, the use of 89Zr is promising for monitoring antibody-b...

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Bibliographic Details
Published in:International journal of molecular sciences 2020-06, Vol.21 (12), p.4309
Main Authors: Yoon, Joon-Kee, Park, Bok-Nam, Ryu, Eun-Kyoung, An, Young-Sil, Lee, Su-Jin
Format: Article
Language:English
Subjects:
Advantages
Antibodies
Binding sites
Breast cancer
Cancer therapies
Epidermal growth factor
Gene expression
Immunotherapy
Kinases
Labeling
Medical imaging
Medical prognosis
Medical research
Metastasis
Monitoring
Monoclonal antibodies
Nanoparticles
Ovarian cancer
Positron emission
Positron emission tomography
Radioisotopes
Review
Studies
Tomography
Tumors
Zirconium isotopes
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Summary:89Zr is an emerging radionuclide that plays an essential role in immuno-positron emission tomography (PET) imaging. The long half-life of 89Zr (t1/2 = 3.3 days) is favorable for evaluating the in vivo distribution of monoclonal antibodies. Thus, the use of 89Zr is promising for monitoring antibody-based cancer therapies. Immuno-PET combines the sensitivity of PET with the specificity of antibodies. A number of studies have been conducted to investigate the feasibility of 89Zr immuno-PET imaging for predicting the efficacy of radioimmunotherapy and antibody therapies, imaging target expression, detecting target-expressing tumors, and the monitoring of anti-cancer chemotherapies. In this review, we summarize the current status of PET imaging using 89Zr in both preclinical and clinical studies by highlighting the use of immuno-PET for the targets of high clinical relevance. We also present 89Zr-PET applications other than immuno-PET, such as nanoparticle imaging and cell tracking. Finally, we discuss the limitations and the ongoing research being performed to overcome the remaining hurdles.
ISSN:1422-0067
1661-6596
1422-0067
DOI:10.3390/ijms21124309