Early assessment of lung aeration using an ultrasound score as a biomarker of developing bronchopulmonary dysplasia: a prospective observational study

The objective of this study was to assess the predictive value of a lung ultrasound (LUS) score in the development of moderate–severe bronchopulmonary dysplasia (sBPD). This was a prospective  observational diagnostic accuracy study in a third-level neonatal intensive care unit. Preterm infants with...

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Bibliographic Details
Published in:Journal of perinatology 2021-01, Vol.41 (1), p.62-68
Main Authors: Oulego-Erroz, Ignacio, Alonso-Quintela, Paula, Terroba-Seara, Sandra, Jiménez-González, Aquilina, Rodríguez-Blanco, Silvia
Format: Article
Language:English
Subjects:
692/53/2421
692/700/459
Aeration
Biomarkers
Bronchopulmonary dysplasia
Bronchopulmonary Dysplasia - diagnostic imaging
Development and progression
Diagnosis
Diagnosis, Ultrasonic
Diagnostic systems
Dysplasia
Gestational age
Health aspects
Humans
Infant
Infant, Newborn
Infant, Premature
Infants
Intensive care
Lung - diagnostic imaging
Lung diseases
Lungs
Medicine
Medicine & Public Health
Neonatal care
Neonates
Newborn babies
Observational studies
Pediatric research
Pediatric Surgery
Pediatrics
Prospective Studies
Pulmonary ventilation
Regression analysis
Risk factors
Ultrasonic imaging
Ultrasonography
Ultrasound
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Summary:The objective of this study was to assess the predictive value of a lung ultrasound (LUS) score in the development of moderate–severe bronchopulmonary dysplasia (sBPD). This was a prospective  observational diagnostic accuracy study in a third-level neonatal intensive care unit. Preterm infants with a gestational age below 32 weeks were included. A LUS score (range 0–24 points) was calculated by assessing aeration semiquantitatively (0–3 points) in eight lung zones on the 7th day of life (DOL) and repeated on the 28th DOL. ROC curves and logistic regression were used for analysis. Forty-two preterm infants were included. The LUS on the 7th DOL had an area under the receiver operating characteristic curve (AUROC) of 0.94 (95% CI: 0.87–1) for the prediction of sBPD (optimal cutoff of ≥8 points: sensitivity 93%, specificity 91%). The LUS score was independently associated with sBPD [OR 2.1 (95% CI: 1.1–3.9), p  = 0.022, for each additional point in the score]. Conclusions:  Lung aeration as assessed by LUS on the 7th DOL may predict the development of sBPD.
ISSN:0743-8346
1476-5543
DOI:10.1038/s41372-020-0724-z