The clinical significance of premature atrial contractions: How frequent should they become predictive of new‐onset atrial fibrillation

Background Although previous studies reported frequent premature atrial contractions(fPACs) increased the risk of adverse cardiovascular outcomes, especially atrial fibrillation(AF), there is a substantial inconsistency between reports concerning the definition of fPAC. In this study, we aimed to in...

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Bibliographic Details
Published in:Annals of noninvasive electrocardiology 2020-05, Vol.25 (3), p.e12718-n/a
Main Authors: Durmaz, Eser, Ikitimur, Baris, Kilickiran Avci, Burcak, Atıcı, Adem, Yurtseven, Ece, Tokdil, Hasan, Ebren, Cansu, Polat, Fuat, Karaca, Orhan, Karadag, Bilgehan, Ongen, Zeki
Format: Article
Language:English
Subjects:
atrial arrhythmias
Cardiac arrhythmia
Cardiovascular disease
Cardiovascular diseases
clinical
Clinical significance
Congestive heart failure
Coronary artery
Coronary artery disease
Diabetes mellitus
electrophysiology
Fibrillation
Health risks
Holter/event recorders
Hypertension
non‐invasive techniques
Original
Patients
Ventricle
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Summary:Background Although previous studies reported frequent premature atrial contractions(fPACs) increased the risk of adverse cardiovascular outcomes, especially atrial fibrillation(AF), there is a substantial inconsistency between reports concerning the definition of fPAC. In this study, we aimed to investigate the relationship between fPAC and cardiovascular outcomes, especially AF. We further searched for a cutoff value of fPAC for prediction of AF. Methods We retrospectively analyzed the ambulatory 24‐hr Holter monitoring records and 392 patients included. Frequent PAC was defined as more than 720 PAC/24 hr as used for frequent ventricular premature beats. Patients’ baseline characteristics, echocardiographic variables and medical history were recorded. Results There were 189 patients with fPAC and 203 patients without fPAC. Patients with fPAC had more comorbidities in terms of hypertension, diabetes mellitus, coronary artery disease and congestive heart failure. CHA2DS2‐VaSc was higher in patients with fPAC. Mean follow‐up duration was 31 months, and the number of patients with new‐onset AF during follow‐up was significantly higher in fPAC group (22% vs. 5%, p 
ISSN:1082-720X
1542-474X
DOI:10.1111/anec.12718