Multivariate analysis of TU wave complex on electrocardiogram in Andersen–Tawil syndrome with KCNJ2 mutations

• Published in: Annals of noninvasive electrocardiology 2020-05, Vol.25 (3), p.e12721-n/a
• Main Authors: Horigome, Hitoshi, Ishikawa, Yasuhiro, Kokubun, Norito, Yoshinaga, Masao, Sumitomo, Naokata, Lin, Lisheng, Kato, Yoshiaki, Tanabe‐Kameda, Yuri, Ohno, Seiko, Nagashima, Masami, Horie, Minoru
• Format: Article
• Language: English
• Subjects: Andersen's syndrome; Andersen–Tawil syndrome; EKG; electrocardiogram; Electrocardiography; Independent component analysis; Multivariate analysis; Mutation; Original; Parameters; Potassium channels (inwardly-rectifying); Principal components analysis; Regression analysis; repolarization; U wave
• ISSN: 1082-720X; 1542-474X
• DOI: 10.1111/anec.12721

Background The exact differences between the TU wave complex of ATS1 and that of healthy individuals remain to be investigated. We sought to characterize the TU wave complex of Andersen–Tawil syndrome type 1 (ATS1) using high frequency electrocardiogram (ECG) data. Methods Electrocardiograms were recorded as time series data with a 2 kHz frequency ECG amplifier in 13 patients with ATS1 (positive for KCNJ2 mutation, ATS1 group) and age‐matched healthy individuals (control group). Conventional ECG parameters were measured, and principal component analysis (PCA) and independent component analysis (ICA) were applied to the TU wave complex. Results Time from T peak (Tp) to U peak (Up), time from bottom (B) to Up, and time from B to U end (BUe, U duration) (0.232 ± 0.018 vs. 0.165 ± 0.017, p