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Functionalization and antimicrobial evaluation of ampicillin, penicillin and vancomycin with Pyrenacantha grandiflora Baill and silver nanoparticles
Some antibiotics have lost their efficacy over common infections and this has led to the search for new antibiotics and chemically altering existing ones for a better control of infectious diseases. In the present study, Pyrenacantha grandiflora tubers extracts were conjugated with ampicillin, penic...
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| Published in: | Scientific reports 2020-07, Vol.10 (1), p.11596, Article 11596 |
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| creator | Murei, Arinao Ayinde, Wasiu B. Gitari, Mugera W. Samie, Amidou |
| description | Some antibiotics have lost their efficacy over common infections and this has led to the search for new antibiotics and chemically altering existing ones for a better control of infectious diseases. In the present study,
Pyrenacantha grandiflora
tubers extracts were conjugated with ampicillin, penicillin, vancomycin and silver nanoparticles and their antimicrobial activity was evaluated against
Escherichia coli
,
Staphylococcus aureus
and
Klebsiella Pneumoniae
. The reactions were confirmed by formation of new functional groups that were identified by Fourier transmission infrared spectroscopy (FTIR). Minimum inhibitory concentrations were determined using the microdilution assay. Minimum bactericidal concentrations and the fractional inhibition concentration index were also determined. FTIR analysis indicated different functional group associated with conjugation. The activity of ampicillin was improved when conjugated with silver nanoparticles against
K. pneumonia
and
E. coli
. Vancomycin showed improvement of activity when conjugated to silver nanoparticles against
K. pneumonia
. Penicillin was improved by acetone extracts and vancomycin showed to be more effective when conjugated with silver nanoparticles and water extracts. The conjugation of
P. grandiflora
with penicillin, ampicillin and vancomycin in the presence of silver nanoparticles improved their biological activities. Therefore, the conjugates are medicinally important and can be used to improve the activity of existing antibiotics. |
| doi_str_mv | 10.1038/s41598-020-68290-x |
| format | article |
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Pyrenacantha grandiflora
tubers extracts were conjugated with ampicillin, penicillin, vancomycin and silver nanoparticles and their antimicrobial activity was evaluated against
Escherichia coli
,
Staphylococcus aureus
and
Klebsiella Pneumoniae
. The reactions were confirmed by formation of new functional groups that were identified by Fourier transmission infrared spectroscopy (FTIR). Minimum inhibitory concentrations were determined using the microdilution assay. Minimum bactericidal concentrations and the fractional inhibition concentration index were also determined. FTIR analysis indicated different functional group associated with conjugation. The activity of ampicillin was improved when conjugated with silver nanoparticles against
K. pneumonia
and
E. coli
. Vancomycin showed improvement of activity when conjugated to silver nanoparticles against
K. pneumonia
. Penicillin was improved by acetone extracts and vancomycin showed to be more effective when conjugated with silver nanoparticles and water extracts. The conjugation of
P. grandiflora
with penicillin, ampicillin and vancomycin in the presence of silver nanoparticles improved their biological activities. Therefore, the conjugates are medicinally important and can be used to improve the activity of existing antibiotics.</description><identifier>ISSN: 2045-2322</identifier><identifier>EISSN: 2045-2322</identifier><identifier>DOI: 10.1038/s41598-020-68290-x</identifier><identifier>PMID: 32665625</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>631/61/168 ; 639/638/11/872 ; Acetone ; Ampicillin ; Ampicillin - chemistry ; Ampicillin - pharmacology ; Anti-Infective Agents - chemistry ; Anti-Infective Agents - pharmacology ; Antibiotics ; Antimicrobial activity ; Antimicrobial agents ; Bacterial Infections - drug therapy ; Bacterial Infections - microbiology ; Drug Synergism ; E coli ; Escherichia coli ; Escherichia coli - drug effects ; Escherichia coli - pathogenicity ; Gold ; Humanities and Social Sciences ; Humans ; Infectious diseases ; Infrared spectroscopy ; Klebsiella pneumoniae - drug effects ; Klebsiella pneumoniae - pathogenicity ; Magnoliopsida - chemistry ; Metal Nanoparticles - chemistry ; Microbial Sensitivity Tests ; multidisciplinary ; Nanoparticles ; Penicillin ; Penicillins - chemistry ; Penicillins - pharmacology ; Pneumonia ; Science ; Science (multidisciplinary) ; Silver ; Silver - chemistry ; Staphylococcus aureus - drug effects ; Staphylococcus aureus - pathogenicity ; Tubers ; Vancomycin ; Vancomycin - chemistry ; Vancomycin - pharmacology</subject><ispartof>Scientific reports, 2020-07, Vol.10 (1), p.11596, Article 11596</ispartof><rights>The Author(s) 2020</rights><rights>The Author(s) 2020. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c511t-a4c6a27f0b98cd7ae8656e8c6bd8e4d1d355d1988fc9a7d4e57c33a7e000aa623</citedby><cites>FETCH-LOGICAL-c511t-a4c6a27f0b98cd7ae8656e8c6bd8e4d1d355d1988fc9a7d4e57c33a7e000aa623</cites><orcidid>0000-0002-3958-749X ; 0000-0003-2296-4778</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.proquest.com/docview/2423654896/fulltextPDF?pq-origsite=primo$$EPDF$$P50$$Gproquest$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.proquest.com/docview/2423654896?pq-origsite=primo$$EHTML$$P50$$Gproquest$$Hfree_for_read</linktohtml><link.rule.ids>230,314,724,777,781,882,25734,27905,27906,36993,44571,53772,53774,74875</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32665625$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Murei, Arinao</creatorcontrib><creatorcontrib>Ayinde, Wasiu B.</creatorcontrib><creatorcontrib>Gitari, Mugera W.</creatorcontrib><creatorcontrib>Samie, Amidou</creatorcontrib><title>Functionalization and antimicrobial evaluation of ampicillin, penicillin and vancomycin with Pyrenacantha grandiflora Baill and silver nanoparticles</title><title>Scientific reports</title><addtitle>Sci Rep</addtitle><addtitle>Sci Rep</addtitle><description>Some antibiotics have lost their efficacy over common infections and this has led to the search for new antibiotics and chemically altering existing ones for a better control of infectious diseases. In the present study,
Pyrenacantha grandiflora
tubers extracts were conjugated with ampicillin, penicillin, vancomycin and silver nanoparticles and their antimicrobial activity was evaluated against
Escherichia coli
,
Staphylococcus aureus
and
Klebsiella Pneumoniae
. The reactions were confirmed by formation of new functional groups that were identified by Fourier transmission infrared spectroscopy (FTIR). Minimum inhibitory concentrations were determined using the microdilution assay. Minimum bactericidal concentrations and the fractional inhibition concentration index were also determined. FTIR analysis indicated different functional group associated with conjugation. The activity of ampicillin was improved when conjugated with silver nanoparticles against
K. pneumonia
and
E. coli
. Vancomycin showed improvement of activity when conjugated to silver nanoparticles against
K. pneumonia
. Penicillin was improved by acetone extracts and vancomycin showed to be more effective when conjugated with silver nanoparticles and water extracts. The conjugation of
P. grandiflora
with penicillin, ampicillin and vancomycin in the presence of silver nanoparticles improved their biological activities. Therefore, the conjugates are medicinally important and can be used to improve the activity of existing antibiotics.</description><subject>631/61/168</subject><subject>639/638/11/872</subject><subject>Acetone</subject><subject>Ampicillin</subject><subject>Ampicillin - chemistry</subject><subject>Ampicillin - pharmacology</subject><subject>Anti-Infective Agents - chemistry</subject><subject>Anti-Infective Agents - pharmacology</subject><subject>Antibiotics</subject><subject>Antimicrobial activity</subject><subject>Antimicrobial agents</subject><subject>Bacterial Infections - drug therapy</subject><subject>Bacterial Infections - microbiology</subject><subject>Drug Synergism</subject><subject>E coli</subject><subject>Escherichia coli</subject><subject>Escherichia coli - drug effects</subject><subject>Escherichia coli - pathogenicity</subject><subject>Gold</subject><subject>Humanities and Social Sciences</subject><subject>Humans</subject><subject>Infectious diseases</subject><subject>Infrared spectroscopy</subject><subject>Klebsiella pneumoniae - 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chemistry</topic><topic>Ampicillin - pharmacology</topic><topic>Anti-Infective Agents - chemistry</topic><topic>Anti-Infective Agents - pharmacology</topic><topic>Antibiotics</topic><topic>Antimicrobial activity</topic><topic>Antimicrobial agents</topic><topic>Bacterial Infections - drug therapy</topic><topic>Bacterial Infections - microbiology</topic><topic>Drug Synergism</topic><topic>E coli</topic><topic>Escherichia coli</topic><topic>Escherichia coli - drug effects</topic><topic>Escherichia coli - pathogenicity</topic><topic>Gold</topic><topic>Humanities and Social Sciences</topic><topic>Humans</topic><topic>Infectious diseases</topic><topic>Infrared spectroscopy</topic><topic>Klebsiella pneumoniae - drug effects</topic><topic>Klebsiella pneumoniae - pathogenicity</topic><topic>Magnoliopsida - chemistry</topic><topic>Metal Nanoparticles - chemistry</topic><topic>Microbial Sensitivity Tests</topic><topic>multidisciplinary</topic><topic>Nanoparticles</topic><topic>Penicillin</topic><topic>Penicillins - 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In the present study,
Pyrenacantha grandiflora
tubers extracts were conjugated with ampicillin, penicillin, vancomycin and silver nanoparticles and their antimicrobial activity was evaluated against
Escherichia coli
,
Staphylococcus aureus
and
Klebsiella Pneumoniae
. The reactions were confirmed by formation of new functional groups that were identified by Fourier transmission infrared spectroscopy (FTIR). Minimum inhibitory concentrations were determined using the microdilution assay. Minimum bactericidal concentrations and the fractional inhibition concentration index were also determined. FTIR analysis indicated different functional group associated with conjugation. The activity of ampicillin was improved when conjugated with silver nanoparticles against
K. pneumonia
and
E. coli
. Vancomycin showed improvement of activity when conjugated to silver nanoparticles against
K. pneumonia
. Penicillin was improved by acetone extracts and vancomycin showed to be more effective when conjugated with silver nanoparticles and water extracts. The conjugation of
P. grandiflora
with penicillin, ampicillin and vancomycin in the presence of silver nanoparticles improved their biological activities. Therefore, the conjugates are medicinally important and can be used to improve the activity of existing antibiotics.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>32665625</pmid><doi>10.1038/s41598-020-68290-x</doi><orcidid>https://orcid.org/0000-0002-3958-749X</orcidid><orcidid>https://orcid.org/0000-0003-2296-4778</orcidid><oa>free_for_read</oa></addata></record> |
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| ispartof | Scientific reports, 2020-07, Vol.10 (1), p.11596, Article 11596 |
| issn | 2045-2322 2045-2322 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7360584 |
| source | Full-Text Journals in Chemistry (Open access); Publicly Available Content (ProQuest); PubMed Central; Springer Nature - nature.com Journals - Fully Open Access |
| subjects | 631/61/168 639/638/11/872 Acetone Ampicillin Ampicillin - chemistry Ampicillin - pharmacology Anti-Infective Agents - chemistry Anti-Infective Agents - pharmacology Antibiotics Antimicrobial activity Antimicrobial agents Bacterial Infections - drug therapy Bacterial Infections - microbiology Drug Synergism E coli Escherichia coli Escherichia coli - drug effects Escherichia coli - pathogenicity Gold Humanities and Social Sciences Humans Infectious diseases Infrared spectroscopy Klebsiella pneumoniae - drug effects Klebsiella pneumoniae - pathogenicity Magnoliopsida - chemistry Metal Nanoparticles - chemistry Microbial Sensitivity Tests multidisciplinary Nanoparticles Penicillin Penicillins - chemistry Penicillins - pharmacology Pneumonia Science Science (multidisciplinary) Silver Silver - chemistry Staphylococcus aureus - drug effects Staphylococcus aureus - pathogenicity Tubers Vancomycin Vancomycin - chemistry Vancomycin - pharmacology |
| title | Functionalization and antimicrobial evaluation of ampicillin, penicillin and vancomycin with Pyrenacantha grandiflora Baill and silver nanoparticles |
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