Near‐Infrared Light Triggered‐Release in Deep Brain Regions Using Ultra‐photosensitive Nanovesicles

Remote and minimally‐invasive modulation of biological systems with light has transformed modern biology and neuroscience. However, light absorption and scattering significantly prevents penetration to deep brain regions. Herein, we describe the use of gold‐coated mechanoresponsive nanovesicles, whi...

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Bibliographic Details
Published in:Angewandte Chemie International Edition 2020-05, Vol.59 (22), p.8608-8615
Main Authors: Xiong, Hejian, Li, Xiuying, Kang, Peiyuan, Perish, John, Neuhaus, Frederik, Ploski, Jonathan E., Kroener, Sven, Ogunyankin, Maria O., Shin, Jeong Eun, Zasadzinski, Joseph A., Wang, Hui, Slesinger, Paul A., Zumbuehl, Andreas, Qin, Zhenpeng
Format: Article
Language:English
Subjects:
Animals
Biomechanical Phenomena
Brain
Brain - metabolism
Brain - radiation effects
Electromagnetic absorption
Gold
Gold - chemistry
gold shell
Infrared lasers
Infrared radiation
Infrared Rays
Liposomes
mechanoresponsive vesicles
Mice
Nanotechnology - methods
near-infrared light
Nervous system
Phospholipids
Phospholipids - metabolism
Photosensitivity
uncaging
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Summary:Remote and minimally‐invasive modulation of biological systems with light has transformed modern biology and neuroscience. However, light absorption and scattering significantly prevents penetration to deep brain regions. Herein, we describe the use of gold‐coated mechanoresponsive nanovesicles, which consist of liposomes made from the artificial phospholipid Rad‐PC‐Rad as a tool for the delivery of bioactive molecules into brain tissue. Near‐infrared picosecond laser pulses activated the gold‐coating on the surface of nanovesicles, creating nanomechanical stress and leading to near‐complete vesicle cargo release in sub‐seconds. Compared to natural phospholipid liposomes, the photo‐release was possible at 40 times lower laser energy. This high photosensitivity enables photorelease of molecules down to a depth of 4 mm in mouse brain. This promising tool provides a versatile platform to optically release functional molecules to modulate brain circuits. Ultra‐photosensitive nanovesicles are developed by coating gold shell on the surface of mechanoresponsive nanovesicles. Gold shell transduces near‐infrared laser pulses to nanomechanical force, leading to efficent cargo release in sub‐seconds. This high photosensitivity enables photorelease of molecules down to a depth of 4 mm in mouse brain.
ISSN:1433-7851
1521-3773
DOI:10.1002/anie.201915296