Expression of miRNA in 5‑FU resistant esophageal cancer

Fluoropyrimidine plus platinum (FP) are chemotherapeutic drugs that are most frequently used to treat esophageal squamous cell carcinoma (ESCC). However, drug resistance often occurs, and the mechanisms of resistance to 5-FU is yet to be determined. The role of micro (mi)RNAs has been well establish...

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Bibliographic Details
Published in:Molecular and clinical oncology 2020-08, Vol.13 (2), p.221-227
Main Authors: Mahawongkajit, Prasit, Tomtitchong, Prakitpunthu
Format: Article
Language:English
Subjects:
Analysis
Cancer therapies
Chemotherapy
Drug resistance
Esophageal cancer
Gene expression
Medical prognosis
MicroRNA
MicroRNAs
Oncology
Radiation therapy
Scientific equipment industry
Software
Squamous cell carcinoma
Surgery
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Summary:Fluoropyrimidine plus platinum (FP) are chemotherapeutic drugs that are most frequently used to treat esophageal squamous cell carcinoma (ESCC). However, drug resistance often occurs, and the mechanisms of resistance to 5-FU is yet to be determined. The role of micro (mi)RNAs has been well established in a variety of human cancers. The aim of the present study was to investigate the expression profile of ESCC, revealing the differential expression between ESCC and 5-FU resistant ESCC. The establishment of a 5-FU resistant (5-FUR) cell lines model provides a way of analyzing the expression of miRNAs in drug resistance. The miRNA expression indicated 50 miRNAs that were upregulated in TE10-5-FUR compared with TE10, while 119 miRNAs were downregulated. The TE11-5-FUR demonstrated 140 miRNAs were upregulated compared with TE11, which exhibited 12 downregulated miRNAs. Both cell lines share the 2 candidate upregulated miRNAs (miR-146a and miR-483-5p) and 5 downregulated miRNAs (miR-34a, miR-141, miR-200b, miR-200c and miR-205). Further studies are required to analyze and evaluate the function of the miRNAs.
ISSN:2049-9450
2049-9469
DOI:10.3892/mco.2020.2070