Cumulative live-birth, perinatal and obstetric outcomes for POSEIDON groups after IVF/ICSI cycles: a single-center retrospective study

Recently, perinatal outcomes and cumulative live birth rate (CLBR) have widely been utilized to assess the fertility outcomes and safety of assisted reproductive technology (ART), but more robust research is needed to address the success rates of live-healthy births resulting from this procedure, pa...

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Published in:Scientific reports 2020-07, Vol.10 (1), p.11822-11822, Article 11822
Main Authors: Abdullah, Raed K., Liu, Nenghui, Zhao, Yuhao, Shuang, Yang, Shen, Zhang, Zeng, Hong, Wu, Jielei
Format: Article
Language:English
Subjects:
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692/308
Adult
Birth Rate
Births
Cesarean section
Diabetes mellitus
Female
Fertility
Fertilization in Vitro
Health risk assessment
Humanities and Social Sciences
Humans
In vitro fertilization
Live Birth
multidisciplinary
Obstetrics
Ovaries
Placenta
Pregnancy
Pregnancy complications
Pregnancy Outcome
Prognosis
Reproductive technologies
Retrospective Studies
Science
Science (multidisciplinary)
Statistical analysis
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Summary:Recently, perinatal outcomes and cumulative live birth rate (CLBR) have widely been utilized to assess the fertility outcomes and safety of assisted reproductive technology (ART), but more robust research is needed to address the success rates of live-healthy births resulting from this procedure, particularly for patients with low prognosis. This study aims to assess and comparative perinatal outcomes and CLBR per cycle of in vitro fertilization/Intracytoplasmic sperm injection (IVF/ICSI) between four groups of low prognosis characterized by POSEIDON criteria. A retrospective assessment was done among infertile women with a low prognosis undergoing IVF/ICSI at a reproductive center in China. Data were collected between January 2011 and December 2015 with a follow-up of at least two years, and censoring was defined by three-cycle completion, discontinuation, or having a live birth. Participants were grouped into 4 groups according to the POSEIDON classification (POSEIDON1, POSEIDON2, POSEIDON3, and POSEIDON4). The main outcomes were perinatal and obstetric outcomes with CLBR per cycle after IVF/ICSI procedure. And IVF/ICSI-technique outcomes as a secondary outcome. Statistical analyses were performed by SPSS, and a p value of
ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-020-68896-1