Serial serum SARS-CoV-2 RNA results in two COVID-19 cases with severe respiratory failure

Coronavirus disease 2019 (COVID-19) is spreading worldwide and poses an imminent threat to public health. We encountered 2 cases of COVID-19 with progression resulting in severe respiratory failure and improvement without any specific treatment. To examine the course of infection, we performed rever...

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Bibliographic Details
Published in:Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy 2020-11, Vol.26 (11), p.1220-1223
Main Authors: Kodama, Tatsuya, Kouzaki, Yuji, Kawano, Shuichi, Obinata, Hirofumi, Taniguchi, Hiroaki, Sasaki, Hisashi, Ota, Shinichiro, Kawana, Akihiko, Tamura, Kaku
Format: Article
Language:English
Subjects:
Adult
Aged
Betacoronavirus - genetics
Betacoronavirus - isolation & purification
Clinical Laboratory Techniques
Coronavirus Infections - blood
Coronavirus Infections - complications
Coronavirus Infections - diagnosis
Coronavirus Infections - virology
COVID-19
COVID-19 Testing
Humans
Male
Pandemics
Pneumonia, Viral - blood
Pneumonia, Viral - complications
Pneumonia, Viral - diagnosis
Pneumonia, Viral - virology
Respiratory Insufficiency - blood
Respiratory Insufficiency - diagnosis
Respiratory Insufficiency - virology
Retrospective Studies
Reverse Transcriptase Polymerase Chain Reaction
RNA, Viral - blood
RNA, Viral - isolation & purification
SARS-CoV-2
Serum SARS-CoV-2 RNA
Severe respiratory failure
Severity of Illness Index
Time Factors
Viremia - complications
Viremia - diagnosis
Viremia - virology
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Summary:Coronavirus disease 2019 (COVID-19) is spreading worldwide and poses an imminent threat to public health. We encountered 2 cases of COVID-19 with progression resulting in severe respiratory failure and improvement without any specific treatment. To examine the course of infection, we performed reverse-transcription (RT) polymerase chain reaction assay with serum specimens, and serum SARS-CoV-2 RNA was detected in both cases when body temperature increased and respiratory status deteriorated. We, then examined, retrospectively and prospectively, the clinical course during hospitalization by performing serial examinations of serum SARS-CoV-2 RNA status. The findings from our cases suggest that not only is detection of viremia useful as a predictive marker of severity, but also serial serum SARS-CoV-2 RNA results can be helpful for predicting the clinical course.
ISSN:1341-321X
1437-7780
DOI:10.1016/j.jiac.2020.07.003