Megalin/lipoprotein receptor-related protein 2 autoimmunity and kidney disease

In this issue of Clinical Kidney Journal, Gamayo et al. describe two cases of anti-low-density lipoprotein receptor-related protein 2 (LRP2) nephropathy. This is a recently described entity that has features of both tubulointerstitial disease and segmental membranous nephropathy. The originality of...

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Bibliographic Details
Published in:Clinical kidney journal 2020-06, Vol.13 (3), p.281-286
Main Authors: Perez-Gomez, Maria V, Sanchez-Niño, Maria D, Ortiz, Alberto
Format: Article
Language:English
Subjects:
Autoimmunity
Cell receptors
Development and progression
Health aspects
Kidney diseases
Lipoproteins
Physiological aspects
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Summary:In this issue of Clinical Kidney Journal, Gamayo et al. describe two cases of anti-low-density lipoprotein receptor-related protein 2 (LRP2) nephropathy. This is a recently described entity that has features of both tubulointerstitial disease and segmental membranous nephropathy. The originality of the present report consists of the association of a disease thought to be rare (only 13 in prior described patients, 11 in the past year) with B-cell lymphoproliferative disease. Together with the finding of a third case among 224 elderly patients studied, this raises the issue of the underdiagnoses of LRP2 nephropathy, on top of the potential association to B-cell malignancy. We now put these findings in context within the wider frame of autoimmunity against megalin/LRP2 and related antigens such as Fx1A and CD69.
ISSN:2048-8505
2048-8513
DOI:10.1093/ckj/sfz171