Nocturnal haemodialysis is associated with a reduced occurrence of low triiodothyronine serum levels in haemodialysed patients

BackgroundEnd-stage renal disease (ESRD) is associated with a broad spectrum of morphological and functional thyroid disorders. Recent studies have shown that low free triiodothyronine (fT3) levels are related to inflammatory status and endothelial activation in ESRD patients on haemodialysis (HD)....

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Published in:Clinical kidney journal 2020-06, Vol.13 (3), p.450-460
Main Authors: Netti, Giuseppe Stefano, Rotondi, Mario, Di Lorenzo, Adelaide, Papantonio, Domenico, Teri, Antonino, Schirone, Morena, Spadaccino, Federica, Croce, Laura, Infante, Barbara, Perulli, Rossella, Coperchini, Francesca, Rocchetti, Maria Teresa, Iannelli, Giuseppina, Fortunato, Francesca, Prato, Rosa, Castellano, Giuseppe, Gesualdo, Loreto, Stallone, Giovanni, Ranieri, Elena, Grandaliano, Giuseppe
Format: Article
Language:English
Subjects:
Hemodialysis
Methods
Original
Physiological aspects
Triiodothyronine
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Summary:BackgroundEnd-stage renal disease (ESRD) is associated with a broad spectrum of morphological and functional thyroid disorders. Recent studies have shown that low free triiodothyronine (fT3) levels are related to inflammatory status and endothelial activation in ESRD patients on haemodialysis (HD). Limited data exist about a possible relationship between dialysis regimen, namely long nocturnal haemodialysis (LNHD), and thyroid function parameters. The aim of this study was to evaluate the relationship between dialysis regimen and thyroid function, and consequently with the main patient outcomes.MethodsTo this purpose, we performed a retrospective, single-centre cohort study including 220 incident chronic HD patients treated during an 8-year period (from January 2010 to December 2017). The main clinical and haematochemical parameters, including thyroid function, were evaluated and related to the main patient outcomes.ResultsPatients with low fT3 levels (3.05 ng/mL) (P 3.05 ng/mL was significantly higher in LNHD patients than in patients treated with diurnal dialysis.ConclusionsOur data suggest that the application of alternative dialysis regimens, also reducing the frequency of low T3, could ameliorate outcomes and therefore reduce the incidence of cardiovascular events in HD patients.
ISSN:2048-8505
2048-8513
DOI:10.1093/ckj/sfaa003