Nonstationary Model of Oxygen Transport in Brain Tissue

The paper addresses the mathematical study of a nonstationary continuum model describing oxygen propagation in cerebral substance. The model allows to estimate the rate of oxygen saturation and stabilization of oxygen concentration in relatively large parts of cerebral tissue. A theoretical and nume...

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Bibliographic Details
Published in:Computational and mathematical methods in medicine 2020, Vol.2020 (2020), p.1-9
Main Authors: Sidorenko, Irina N., Turova, Varvara, Botkin, Nikolai, Chebotarev, Alexander Yu, Kovtanyuk, Andrey E., Lampe, Renée
Format: Article
Language:English
Subjects:
Animals
Blood-Brain Barrier
Brain - blood supply
Brain - metabolism
Computational Biology
Computer Simulation
Humans
Hypoxia, Brain - metabolism
Mathematical Concepts
Models, Neurological
Nonlinear Dynamics
Oxygen - blood
Oxygen - metabolism
Oxygen Consumption
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Summary:The paper addresses the mathematical study of a nonstationary continuum model describing oxygen propagation in cerebral substance. The model allows to estimate the rate of oxygen saturation and stabilization of oxygen concentration in relatively large parts of cerebral tissue. A theoretical and numerical analysis of the model is performed. The unique solvability of the underlying initial-boundary value problem for a system of coupled nonlinear parabolic equations is proved. In the numerical experiment, the tissue oxygen saturation after hypoxia is analyzed for the case when a sufficient amount of oxygen begins to flow into the capillary network. A fast stabilization of the tissue oxygen concentration is demonstrated. The reliability of the results of the numerical simulation is discussed.
ISSN:1748-670X
1748-6718
DOI:10.1155/2020/4861654