Bridging the gap: Mechanisms of plasticity and repair after pediatric TBI

Traumatic brain injury is the leading cause of death and disability in the United States, and may be associated with long lasting impairments into adulthood. The multitude of ongoing neurobiological processes that occur during brain maturation confer both considerable vulnerability to TBI but may al...

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Bibliographic Details
Published in:Experimental neurology 2019-08, Vol.318, p.78-91
Main Authors: Sta Maria, Naomi S., Sargolzaei, Saman, Prins, Mayumi L., Dennis, Emily L., Asarnow, Robert F., Hovda, David A., Harris, Neil G., Giza, Christopher C.
Format: Article
Language:English
Subjects:
Brain Injuries, Traumatic - physiopathology
Child
Child, Preschool
Development
Humans
Infant
Infant, Newborn
Nerve Regeneration - physiology
Neuronal Plasticity - physiology
Pediatric TBI
Plasticity
Recovery of Function - physiology
Traumatic brain injury
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Summary:Traumatic brain injury is the leading cause of death and disability in the United States, and may be associated with long lasting impairments into adulthood. The multitude of ongoing neurobiological processes that occur during brain maturation confer both considerable vulnerability to TBI but may also provide adaptability and potential for recovery. This review will examine and synthesize our current understanding of developmental neurobiology in the context of pediatric TBI. Delineating this biology will facilitate more targeted initial care, mechanism-based therapeutic interventions and better long-term prognostication and follow-up.
ISSN:0014-4886
1090-2430
DOI:10.1016/j.expneurol.2019.04.016