Delayed cytokinesis generates multinuclearity and potential advantages in the amoeba Acanthamoebacastellanii Neff strain

Multinuclearity is a widespread phenomenon across the living world, yet how it is achieved, and the potential related advantages, are not systematically understood. In this study, we investigate multinuclearity in amoebae. We observe that non-adherent amoebae are giant multinucleate cells compared t...

Full description

Saved in:
Bibliographic Details
Published in:Scientific reports 2020-07, Vol.10 (1)
Main Authors: Quinet, Théo, Samba-Louaka, Ascel, Héchard, Yann, Van Doninck, Karine, Van der Henst, Charles
Format: Article
Language:English
Subjects:
631/158/855
631/158/857
631/326/417
Acanthamoeba castellanii
Adhesion
Amoeba
Biology
Cysts
Cytokinesis
Hartmannella rhysodes
Humanities and Social Sciences
Infections
Morphology
multidisciplinary
Naegleria gruberi
Nuclei
Pathogens
Population growth
Science
Science (multidisciplinary)
Swimming pools
Vermamoeba vermiformis
Citations: Items that this one cites
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Multinuclearity is a widespread phenomenon across the living world, yet how it is achieved, and the potential related advantages, are not systematically understood. In this study, we investigate multinuclearity in amoebae. We observe that non-adherent amoebae are giant multinucleate cells compared to adherent ones. The cells solve their multinuclearity by a stretchy cytokinesis process with cytosolic bridge formation when adherence resumes. After initial adhesion to a new substrate, the progeny of the multinucleate cells is more numerous than the sibling cells generated from uninucleate amoebae. Hence, multinucleate amoebae show an advantage for population growth when the number of cells is quantified over time. Multiple nuclei per cell are observed in different amoeba species, and the lack of adhesion induces multinuclearity in diverse protists such as Acanthamoeba castellanii , Vermamoeba vermiformis , Naegleria gruberi and Hartmannella rhysodes . In this study, we observe that agitation induces a cytokinesis delay, which promotes multinuclearity. Hence, we propose the hypothesis that multinuclearity represents a physiological adaptation under non-adherent conditions that can lead to biologically relevant advantages.
ISSN:2045-2322
DOI:10.1038/s41598-020-68694-9