Prognostic value of systemic inflammatory markers for oral cancer patients based on the 8th edition of AJCC staging system

It has been recognized that systemic inflammatory markers (SIMs) are associated with patient survival in various types of cancer. This study aimed to determine the optimal cut-off values, and to evaluate the prognostic performance of SIMs for oral squamous cell carcinoma (OSCC) within the framework...

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Bibliographic Details
Published in:Scientific reports 2020-07, Vol.10 (1), p.12111-12111, Article 12111
Main Authors: Lee, Sanghoon, Kim, Dong Wook, Kwon, Sunmo, Kim, Hyung Jun, Cha, In-Ho, Nam, Woong
Format: Article
Language:English
Subjects:
692/4028/546
692/4028/67/1536/1665
692/499
Adult
Aged
Aged, 80 and over
Biomarkers, Tumor - blood
Cancer
Carcinoma, Squamous Cell - immunology
Carcinoma, Squamous Cell - pathology
Carcinoma, Squamous Cell - surgery
Female
Humanities and Social Sciences
Humans
Inflammation
Lymph nodes
Lymphocyte Count
Lymphocytes
Male
Middle Aged
Mouth Neoplasms - immunology
Mouth Neoplasms - pathology
Mouth Neoplasms - surgery
multidisciplinary
Neoplasm Staging
Neutrophils - metabolism
Oral cancer
Oral squamous cell carcinoma
Oral Surgical Procedures
Peripheral blood
Platelet Count
Prognosis
Risk factors
Science
Science (multidisciplinary)
Squamous cell carcinoma
Surgery
Survival
Survival Analysis
Treatment Outcome
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Summary:It has been recognized that systemic inflammatory markers (SIMs) are associated with patient survival in various types of cancer. This study aimed to determine the optimal cut-off values, and to evaluate the prognostic performance of SIMs for oral squamous cell carcinoma (OSCC) within the framework of the American Joint Committee of Cancer (AJCC) cancer staging manual, 8th edition. Records were collected for a total 291 patients who had had a peripheral blood test within 1 week prior to surgery and had undergone the surgical resection of OSCC in a single institution between 2005 and 2018. The cut-off values of SIMs were obtained, and the survival analyses for overall survival (OS) and disease-free survival (DFS) were performed. Multivariate analyses incorporating other clinicopathologic factors were performed to verify the independent risk factors for survival. The cut-off values of neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) were 2.23, 135.14 for OS and 2.16, 131.07 for DFS, respectively, demonstrating a significant association for OS and DFS in OSCC. AJCC pathologic regional lymph node category (pN) ( P  
ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-020-68991-3