Functional lupus anticoagulant testing in a large retrospective cohort of thrombosis patients with direct oral anticoagulants

Functional tests for lupus anticoagulants (LA) as part of a thrombophilia workup are commonly performed in patients under anticoagulant therapy that may interfere with assay results. There is no consensus on how these tests should be assessed in patients on direct oral anticoagulants (DOACs). In thi...

Full description

Saved in:
Bibliographic Details
Published in:Scientific reports 2020-07, Vol.10 (1), p.12221-12221, Article 12221
Main Authors: Reda, Sara, Brügelmann, Anna, Müller, Jens, Oldenburg, Johannes, Pötzsch, Bernd, Rühl, Heiko
Format: Article
Language:English
Subjects:
692/53/2421
692/699/75/593/1839
Anticoagulants
Antiphospholipid antibodies
Humanities and Social Sciences
Lupus
multidisciplinary
Plasma levels
Science
Science (multidisciplinary)
Systemic lupus erythematosus
Thromboembolism
Thrombophilia
Thrombosis
Venom
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Functional tests for lupus anticoagulants (LA) as part of a thrombophilia workup are commonly performed in patients under anticoagulant therapy that may interfere with assay results. There is no consensus on how these tests should be assessed in patients on direct oral anticoagulants (DOACs). In this retrospective cohort study, we analysed data from patients with a history of thrombosis in whom dilute Russell viper venom time (dRVVT), LA-sensitive aPTT, and solid phase assays for antiphospholipid antibodies (aPL) were performed (n = 3,147, thereof 588 on rivaroxaban, 144 on apixaban, 1,179 on other anticoagulant drugs). The dRVVT ratio was correlated with rivaroxaban (r = 0.30, P  
ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-020-69199-1