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Correlation of electroretinography components with visual function and prognosis of central retinal artery occlusion
We investigated the full-field electroretinographic (ERG) parameters with visual function and prognosis in central retinal artery occlusion (CRAO), according to its severity. 110 affected eyes of CRAO patients were enrolled and compared with fellow uninvolved eyes (N = 110) and normal control eyes (...
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| Published in: | Scientific reports 2020-07, Vol.10 (1), p.12146, Article 12146 |
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| description | We investigated the full-field electroretinographic (ERG) parameters with visual function and prognosis in central retinal artery occlusion (CRAO), according to its severity. 110 affected eyes of CRAO patients were enrolled and compared with fellow uninvolved eyes (N = 110) and normal control eyes (N = 30). B/A ratio and photopic negative response amplitude (PhNR) resulted in statistically significant differences among the CRAO subgroups according to the severity of retinal ischemia. Amplitudes of PhNR indicating ganglion cell function showed a more marked decline in mild to severe ischemia than those of the B-wave. In terms of visual function and outcome, baseline visual acuity and visual field defects were correlated with B/A ratio only (both,
P
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| doi_str_mv | 10.1038/s41598-020-68957-5 |
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P
< .001), whereas improvements in visual acuity and visual field were correlated with B-wave amplitude in dark-adapted 3.0 (
P
= .004 and .006), B/A ratio (
P
= .023 and .008), and PhNR amplitude (
P
< .001 and .004). These three ERG parameters were found to be credible predictive factors of visual prognosis. In conclusion, B-wave amplitude in dark-adapted 3.0, B/A ratio, and PhNR amplitude changes in eyes with CRAO are associated with baseline features related to the severity of retinal ischemia, and these are correlated with visual function and prognosis.</description><identifier>ISSN: 2045-2322</identifier><identifier>EISSN: 2045-2322</identifier><identifier>DOI: 10.1038/s41598-020-68957-5</identifier><identifier>PMID: 32699229</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>692/699/3161/3175 ; 692/699/3161/3178 ; Acuity ; Adult ; Aged ; Area Under Curve ; Electroretinograms ; Electroretinography ; Eye ; Eye - diagnostic imaging ; Female ; Fluorescein Angiography ; Humanities and Social Sciences ; Humans ; Ischemia ; Male ; Middle Aged ; multidisciplinary ; Occlusion ; Prognosis ; Retina ; Retinal Artery Occlusion - diagnosis ; Retinal Artery Occlusion - pathology ; ROC Curve ; Science ; Science (multidisciplinary) ; Severity of Illness Index ; Statistical analysis ; Tomography, Optical Coherence ; Visual field ; Visual Fields - physiology ; Visual perception</subject><ispartof>Scientific reports, 2020-07, Vol.10 (1), p.12146, Article 12146</ispartof><rights>The Author(s) 2020</rights><rights>The Author(s) 2020. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c474t-26ae0d2c3a7047abb89c21331212a57ee126094989a74401f593dc12362c84a63</citedby><cites>FETCH-LOGICAL-c474t-26ae0d2c3a7047abb89c21331212a57ee126094989a74401f593dc12362c84a63</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.proquest.com/docview/2426006598/fulltextPDF?pq-origsite=primo$$EPDF$$P50$$Gproquest$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.proquest.com/docview/2426006598?pq-origsite=primo$$EHTML$$P50$$Gproquest$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,25731,27901,27902,36989,44566,53766,53768,74869</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32699229$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kim, Hyeong Min</creatorcontrib><creatorcontrib>Park, Kyu Hyung</creatorcontrib><creatorcontrib>Woo, Se Joon</creatorcontrib><title>Correlation of electroretinography components with visual function and prognosis of central retinal artery occlusion</title><title>Scientific reports</title><addtitle>Sci Rep</addtitle><addtitle>Sci Rep</addtitle><description>We investigated the full-field electroretinographic (ERG) parameters with visual function and prognosis in central retinal artery occlusion (CRAO), according to its severity. 110 affected eyes of CRAO patients were enrolled and compared with fellow uninvolved eyes (N = 110) and normal control eyes (N = 30). B/A ratio and photopic negative response amplitude (PhNR) resulted in statistically significant differences among the CRAO subgroups according to the severity of retinal ischemia. Amplitudes of PhNR indicating ganglion cell function showed a more marked decline in mild to severe ischemia than those of the B-wave. In terms of visual function and outcome, baseline visual acuity and visual field defects were correlated with B/A ratio only (both,
P
< .001), whereas improvements in visual acuity and visual field were correlated with B-wave amplitude in dark-adapted 3.0 (
P
= .004 and .006), B/A ratio (
P
= .023 and .008), and PhNR amplitude (
P
< .001 and .004). These three ERG parameters were found to be credible predictive factors of visual prognosis. In conclusion, B-wave amplitude in dark-adapted 3.0, B/A ratio, and PhNR amplitude changes in eyes with CRAO are associated with baseline features related to the severity of retinal ischemia, and these are correlated with visual function and prognosis.</description><subject>692/699/3161/3175</subject><subject>692/699/3161/3178</subject><subject>Acuity</subject><subject>Adult</subject><subject>Aged</subject><subject>Area Under Curve</subject><subject>Electroretinograms</subject><subject>Electroretinography</subject><subject>Eye</subject><subject>Eye - diagnostic imaging</subject><subject>Female</subject><subject>Fluorescein Angiography</subject><subject>Humanities and Social Sciences</subject><subject>Humans</subject><subject>Ischemia</subject><subject>Male</subject><subject>Middle Aged</subject><subject>multidisciplinary</subject><subject>Occlusion</subject><subject>Prognosis</subject><subject>Retina</subject><subject>Retinal Artery Occlusion - diagnosis</subject><subject>Retinal Artery Occlusion - pathology</subject><subject>ROC Curve</subject><subject>Science</subject><subject>Science (multidisciplinary)</subject><subject>Severity of Illness Index</subject><subject>Statistical analysis</subject><subject>Tomography, Optical Coherence</subject><subject>Visual field</subject><subject>Visual Fields - physiology</subject><subject>Visual perception</subject><issn>2045-2322</issn><issn>2045-2322</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>PIMPY</sourceid><recordid>eNp9kU1LAzEQhoMoVmr_gAdZ8LyaTLIfuQhS_IKCFz2HNM22W7bJmmQr_fem3VrrxVwmMO_7zgwPQlcE3xJMyzvPSMbLFANO85JnRZqdoAvALEuBApwe_Qdo5P0Sx5cBZ4SfowGFnHMAfoHC2DqnGxlqaxJbJbrRKjjrdKiNnTvZLjaJsqvWGm2CT77qsEjWte9kk1SdUTubNLOkdXZurK_9NkRFrYuKXUqs0gXtNolVqul8dFyis0o2Xo_2dYg-nh7fxy_p5O35dfwwSRUrWEghlxrPQFFZYFbI6bTkCgilBAjIrNCaQI454yWXBWOYVBmnM0WA5qBKJnM6RPd9bttNV3q2X0u0rl5JtxFW1uJvx9QLMbdrUdAiB4AYcLMPcPaz0z6Ipe1cPMkLYHE4ziODqIJepZz13unqMIFgsYUlelgiwhI7WCKLpuvj3Q6WHzRRQHuBjy0z1-539j-x3zUmosQ</recordid><startdate>20200722</startdate><enddate>20200722</enddate><creator>Kim, Hyeong Min</creator><creator>Park, Kyu Hyung</creator><creator>Woo, Se Joon</creator><general>Nature Publishing Group UK</general><general>Nature Publishing Group</general><scope>C6C</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>88I</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>M7P</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>5PM</scope></search><sort><creationdate>20200722</creationdate><title>Correlation of electroretinography components with visual function and prognosis of central retinal artery occlusion</title><author>Kim, Hyeong Min ; Park, Kyu Hyung ; Woo, Se Joon</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c474t-26ae0d2c3a7047abb89c21331212a57ee126094989a74401f593dc12362c84a63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>692/699/3161/3175</topic><topic>692/699/3161/3178</topic><topic>Acuity</topic><topic>Adult</topic><topic>Aged</topic><topic>Area Under Curve</topic><topic>Electroretinograms</topic><topic>Electroretinography</topic><topic>Eye</topic><topic>Eye - diagnostic imaging</topic><topic>Female</topic><topic>Fluorescein Angiography</topic><topic>Humanities and Social Sciences</topic><topic>Humans</topic><topic>Ischemia</topic><topic>Male</topic><topic>Middle Aged</topic><topic>multidisciplinary</topic><topic>Occlusion</topic><topic>Prognosis</topic><topic>Retina</topic><topic>Retinal Artery Occlusion - diagnosis</topic><topic>Retinal Artery Occlusion - pathology</topic><topic>ROC Curve</topic><topic>Science</topic><topic>Science (multidisciplinary)</topic><topic>Severity of Illness Index</topic><topic>Statistical analysis</topic><topic>Tomography, Optical Coherence</topic><topic>Visual field</topic><topic>Visual Fields - physiology</topic><topic>Visual perception</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kim, Hyeong Min</creatorcontrib><creatorcontrib>Park, Kyu Hyung</creatorcontrib><creatorcontrib>Woo, Se Joon</creatorcontrib><collection>Springer Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Biological Sciences</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Science Database</collection><collection>Biological Science Database</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central Basic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Scientific reports</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kim, Hyeong Min</au><au>Park, Kyu Hyung</au><au>Woo, Se Joon</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Correlation of electroretinography components with visual function and prognosis of central retinal artery occlusion</atitle><jtitle>Scientific reports</jtitle><stitle>Sci Rep</stitle><addtitle>Sci Rep</addtitle><date>2020-07-22</date><risdate>2020</risdate><volume>10</volume><issue>1</issue><spage>12146</spage><pages>12146-</pages><artnum>12146</artnum><issn>2045-2322</issn><eissn>2045-2322</eissn><abstract>We investigated the full-field electroretinographic (ERG) parameters with visual function and prognosis in central retinal artery occlusion (CRAO), according to its severity. 110 affected eyes of CRAO patients were enrolled and compared with fellow uninvolved eyes (N = 110) and normal control eyes (N = 30). B/A ratio and photopic negative response amplitude (PhNR) resulted in statistically significant differences among the CRAO subgroups according to the severity of retinal ischemia. Amplitudes of PhNR indicating ganglion cell function showed a more marked decline in mild to severe ischemia than those of the B-wave. In terms of visual function and outcome, baseline visual acuity and visual field defects were correlated with B/A ratio only (both,
P
< .001), whereas improvements in visual acuity and visual field were correlated with B-wave amplitude in dark-adapted 3.0 (
P
= .004 and .006), B/A ratio (
P
= .023 and .008), and PhNR amplitude (
P
< .001 and .004). These three ERG parameters were found to be credible predictive factors of visual prognosis. In conclusion, B-wave amplitude in dark-adapted 3.0, B/A ratio, and PhNR amplitude changes in eyes with CRAO are associated with baseline features related to the severity of retinal ischemia, and these are correlated with visual function and prognosis.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>32699229</pmid><doi>10.1038/s41598-020-68957-5</doi><oa>free_for_read</oa></addata></record> |
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| subjects | 692/699/3161/3175 692/699/3161/3178 Acuity Adult Aged Area Under Curve Electroretinograms Electroretinography Eye Eye - diagnostic imaging Female Fluorescein Angiography Humanities and Social Sciences Humans Ischemia Male Middle Aged multidisciplinary Occlusion Prognosis Retina Retinal Artery Occlusion - diagnosis Retinal Artery Occlusion - pathology ROC Curve Science Science (multidisciplinary) Severity of Illness Index Statistical analysis Tomography, Optical Coherence Visual field Visual Fields - physiology Visual perception |
| title | Correlation of electroretinography components with visual function and prognosis of central retinal artery occlusion |
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