Resolution of Treatment-Refractory Prurigo Nodularis With Dupilumab: A Case Series

Prurigo nodularis is a pruritic skin condition that can present therapeutic challenges. We present a series of three patients diagnosed with prurigo nodularis who had failed several commonly trialed therapies, but experienced relief from symptoms and improvement in skin lesions following initiation...

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Bibliographic Details
Published in:Curēus (Palo Alto, CA) CA), 2020-06, Vol.12 (6)
Main Authors: Wieser, Jill K, Mercurio, Mary Gail, Somers, Kathryn
Format: Article
Language:English
Subjects:
Asthma
Biopsy
Case reports
Dermatitis
Dermatology
Eczema
Histamine
Immunotherapy
Monoclonal antibodies
Patients
Pruritus
Quality of life
Skin diseases
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Summary:Prurigo nodularis is a pruritic skin condition that can present therapeutic challenges. We present a series of three patients diagnosed with prurigo nodularis who had failed several commonly trialed therapies, but experienced relief from symptoms and improvement in skin lesions following initiation of dupilumab therapy. All patients in this series lacked a diagnosis of atopic dermatitis and had lesions on the lower extremities, although other locations such as the trunk were also involved. Continued study of dupilumab in patients with prurigo nodularis is advocated.
ISSN:2168-8184
2168-8184
DOI:10.7759/cureus.8737