Clinical significance of ring finger protein 2 high expression in skin squamous cell carcinoma

Although ring finger protein 2 (RNF2) serves an important role in the occurrence, development and regulation of various types of cancer, RNF2 expression in skin squamous cell carcinoma (SCC) remains unknown. The aim of the present study was to investigate the role of RNF2 expression in SCC and adjac...

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Bibliographic Details
Published in:Oncology letters 2020-08, Vol.20 (2), p.1111-1118
Main Authors: Ling, Bai, Yao, Ming, Li, Gongqi, Liu, Jun, Liu, Bin, Wang, Wei, Jiang, Bin
Format: Article
Language:English
Subjects:
Age
Antibodies
Breast cancer
Cancer metastasis
Cancer therapies
Chemotherapy
Clinical significance
Ethanol
Gene expression
Genes
Hospitals
Immunohistochemistry
Laboratories
Medical prognosis
Medical research
Melanoma
Metastasis
Oxidative stress
Patients
Proteins
Radiation therapy
RNA
Skin
Skin cancer
Squamous cell carcinoma
Tumors
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Summary:Although ring finger protein 2 (RNF2) serves an important role in the occurrence, development and regulation of various types of cancer, RNF2 expression in skin squamous cell carcinoma (SCC) remains unknown. The aim of the present study was to investigate the role of RNF2 expression in SCC and adjacent tissues from patients. The protein and gene expression levels of RNF2 in SCC and adjacent tissues were detected by immunohistochemistry (IHC), western blot analysis and semi-quantitative reverse transcription (RT) PCR. Single factor analysis was used to study the association between RNF2 expression level and the clinicopathological characteristics of patients with SCC. Multifactor Cox survival analysis was used to examine the association between RNF2 expression and the overall survival rate of postoperative patients with SCC. The results from IHC staining demonstrated that the positive expression rate of RNF2 was 84.68% (210/248) and 56.05% (139/248) in SCC and in adjacent tissues, respectively. Furthermore, results from western blot analysis demonstrated that RNF2 protein expression in SCC tissues was significantly higher compared with that in the adjacent tissues (P
ISSN:1792-1074
1792-1082
DOI:10.3892/ol.2020.11666