Sars-CoV-2 in pregnancy: Why is it better than expected?

Since the outbreak of Coronavirus disease in December 2019, information specific to pregnancy remains limited and controversial. Based on data from previous reports, it has been noticed that contrary to prior pandemics such as SARS, MERS and H1N1 and although pregnancy is usually considered as a con...

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Bibliographic Details
Published in:European journal of obstetrics & gynecology and reproductive biology 2020-09, Vol.252, p.476-478
Main Authors: Ghi, Tullio, di Pasquo, Elvira, Mekinian, Arsene, Calza, Leonardo, Frusca, Tiziana
Format: Article
Language:English
Subjects:
Betacoronavirus - immunology
Coronavirus Infections - immunology
Coronavirus Infections - virology
COVID-19
Cytokines - immunology
Female
Humans
Immunology
Inflammation
Pandemics
Pneumonia, Viral - immunology
Pneumonia, Viral - virology
Pregnancy
Pregnancy Complications, Infectious - immunology
Pregnancy Complications, Infectious - virology
Review
SARS-CoV-2
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Summary:Since the outbreak of Coronavirus disease in December 2019, information specific to pregnancy remains limited and controversial. Based on data from previous reports, it has been noticed that contrary to prior pandemics such as SARS, MERS and H1N1 and although pregnancy is usually considered as a condition of high susceptibility to viral infections, new SARS-CoV2 infection seems to have a more benign clinical course when affecting pregnant women. We speculate that during pregnancy the physiological “silencing” of the Th1 pro-inflammatory response may blunt the cytokines storm which is thought to play a key-role in the pathogenesis of the severe complications of Covid-19.
ISSN:0301-2115
1872-7654
DOI:10.1016/j.ejogrb.2020.07.025