Recent Advancements in CD47 Signal Transduction Pathways Involved in Vascular Diseases

Cardiovascular and cerebrovascular diseases caused by atherosclerosis have a high disability rate and reduce the quality of life of the population. Therefore, understanding the mechanism of atherosclerosis and its control may interfere with the progression of atherosclerosis and thus control the occ...

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Bibliographic Details
Published in:BioMed research international 2020, Vol.2020 (2020), p.1-11
Main Authors: Ma, Di, Hu, Jian, Chen, Ying, Dou, Manman, Xing, Yingqi
Format: Article
Language:English
Subjects:
Angiogenesis
Animals
Antiangiogenics
Apoptosis
Arteriosclerosis
Atherosclerosis
CD47 Antigen - metabolism
Cell adhesion & migration
Cell growth
Cellular signal transduction
Cerebrovascular diseases
Chemokines
Cytokines
Cytokines - metabolism
Disease
Disease prevention
Endothelium
Growth factors
Health aspects
Humans
Inflammation
Inflammation - pathology
Interleukin 1
Kinases
Lipids
Lymphocytes
Molecular Targeted Therapy
Pathogenesis
Phosphatase
Proteins
Quality of life
Review
Signal Transduction
Smooth muscle
Stroke
T cells
Tumor necrosis factor-TNF
Vascular diseases
Vascular Diseases - immunology
Vascular Diseases - metabolism
Vascular endothelial growth factor
Veins & arteries
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Summary:Cardiovascular and cerebrovascular diseases caused by atherosclerosis have a high disability rate and reduce the quality of life of the population. Therefore, understanding the mechanism of atherosclerosis and its control may interfere with the progression of atherosclerosis and thus control the occurrence of diseases closely related to atherosclerosis. TSP-1 is a factor that has been found to have an antiangiogenic effect, and CD47, as the receptor of TSP-1, can participate in the regulation of antiangiogenesis of atherosclerosis. VEGF is an important regulator of angiogenesis, and TSP-1/CD47 can cause VEGF and its downstream expression. Therefore, the TSP-1/CD47/VEGF/VEGFR2 signal may have an important influence on atherosclerosis. In addition, some inflammatory factors, such as IL-1 and NLRP3, can also affect atherosclerosis. This review will be expounded focusing on the pathogenesis and influencing factors of atherosclerosis.
ISSN:2314-6133
2314-6141
DOI:10.1155/2020/4749135