The cohesin complex in mammalian meiosis

Cohesin is an evolutionary conserved multi‐protein complex that plays a pivotal role in chromosome dynamics. It plays a role both in sister chromatid cohesion and in establishing higher order chromosome architecture, in somatic and germ cells. Notably, the cohesin complex in meiosis differs from tha...

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Bibliographic Details
Published in:Genes to cells : devoted to molecular & cellular mechanisms 2019-01, Vol.24 (1), p.6-30
Main Author: Ishiguro, Kei‐ichiro
Format: Article
Language:English
Subjects:
Animals
Cell Cycle Proteins - metabolism
Chromosomal Proteins, Non-Histone - metabolism
Chromosome Pairing
Chromosomes
Chromosomes, Mammalian - metabolism
Cohesin
Cohesins
Evolutionary conservation
Germ cells
Mammals
Mammals - metabolism
Meiosis
Mitosis
Recombination
Review
Yeast
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Summary:Cohesin is an evolutionary conserved multi‐protein complex that plays a pivotal role in chromosome dynamics. It plays a role both in sister chromatid cohesion and in establishing higher order chromosome architecture, in somatic and germ cells. Notably, the cohesin complex in meiosis differs from that in mitosis. In mammalian meiosis, distinct types of cohesin complexes are produced by altering the combination of meiosis‐specific subunits. The meiosis‐specific subunits endow the cohesin complex with specific functions for numerous meiosis‐associated chromosomal events, such as chromosome axis formation, homologue association, meiotic recombination and centromeric cohesion for sister kinetochore geometry. This review mainly focuses on the cohesin complex in mammalian meiosis, pointing out the differences in its roles from those in mitosis. Further, common and divergent aspects of the meiosis‐specific cohesin complex between mammals and other organisms are discussed. In mammalian meiosis, distinct types of cohesin complexes are produced by altering the combination of meiosis‐specific subunits. The meiosis‐specific subunits endow the cohesin complex with specific functions for numerous meiosis‐associated chromosomal events. This review mainly focuses on the cohesin complex in mammalian meiosis, pointing out the differences in its roles from those in mitosis.
ISSN:1356-9597
1365-2443
DOI:10.1111/gtc.12652