Comparison of bone-to-implant contact and bone volume around implants placed with or without site preparation: a histomorphometric study in rabbits

The objective of this in vivo study was to compare bone-to-implant contact (BIC) and bone area fraction occupancy (BAFO) values of a new implant, designed to be inserted without bone preparation, using two different preparation protocols: no site preparation and prior limited cortical perforation, v...

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Bibliographic Details
Published in:Scientific reports 2020-07, Vol.10 (1), p.12446-12446, Article 12446
Main Authors: Folkman, Merav, Becker, Alina, Meinster, Isabelle, Masri, Mahmoud, Ormianer, Zeev
Format: Article
Language:English
Subjects:
692/308
692/308/2778
Animals
Bone implants
Bone-Implant Interface - physiology
Dental Implantation - instrumentation
Dental Implantation - methods
Dental Implants
Dental Prosthesis Design
Design
Humanities and Social Sciences
Models, Animal
multidisciplinary
Osseointegration
Osseointegration - physiology
Osteotomy
Rabbits
Science
Science (multidisciplinary)
Statistical analysis
Surface Properties
Tibia - physiology
Tibia - surgery
Transplants & implants
Variance analysis
Wound Healing - physiology
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Summary:The objective of this in vivo study was to compare bone-to-implant contact (BIC) and bone area fraction occupancy (BAFO) values of a new implant, designed to be inserted without bone preparation, using two different preparation protocols: no site preparation and prior limited cortical perforation, versus the values of a control implant using a conventional drilling protocol. Forty-one implants were inserted in 13 rabbits. Thirteen test implants with a new thread design were inserted using no bone preparation (NP), 14 test implants were inserted with limited cortical perforation (CP), and 14 conventional implants served as control. Five animals were sacrificed after 21 days and eight animals after 42 days. Histomorphometric analysis was performed and percentage of BIC and BAFO values were measured. ANOVA with Tukey post hoc and Mann–Whitney nonparametric tests were calculated to compare between the groups. Statistical analysis showed no significant difference in the measured values between any of the groups, neither compered by implant nor by compered day. The results demonstrated that biological osseointegration parameters of implant that was inserted without any bone preparation was non-inferior compared to conventional preparation. The clinical relevance is that novel implant designs may not require bone preparation prior to placement.
ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-020-69455-4