Extracellular vesicle-based Nanotherapeutics: Emerging frontiers in anti-inflammatory therapy

Dysregulated inflammation is a complicated pathological process involved in various diseases, and the treatment of inflammation-linked disorders currently represents an enormous global burden. Extracellular vesicles (EVs) are nanosized, lipid membrane-enclosed vesicles secreted by virtually all type...

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Bibliographic Details
Published in:Theranostics 2020-01, Vol.10 (18), p.8111-8129
Main Authors: Tang, Tao-Tao, Wang, Bin, Lv, Lin-Li, Liu, Bi-Cheng
Format: Article
Language:English
Subjects:
Anti-Inflammatory Agents - administration & dosage
Antibodies
Cell adhesion & migration
Cell Engineering
Drug Carriers - chemistry
Extracellular Vesicles - chemistry
Extracellular Vesicles - genetics
Extracellular Vesicles - immunology
Genetic Engineering
Humans
Immunologic Surveillance
Inflammation
Inflammation - drug therapy
Nanomedicine - methods
Peptides
Proteins
Review
Surface Properties
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Summary:Dysregulated inflammation is a complicated pathological process involved in various diseases, and the treatment of inflammation-linked disorders currently represents an enormous global burden. Extracellular vesicles (EVs) are nanosized, lipid membrane-enclosed vesicles secreted by virtually all types of cells, which act as an important intercellular communicative medium. Considering their capacity to transfer bioactive substances, both unmodified and engineered EVs are increasingly being explored as potential therapeutic agents or therapeutic vehicles. Moreover, as the nature's own delivery tool, EVs possess many desirable advantages, such as stability, biocompatibility, low immunogenicity, low toxicity, and biological barrier permeability. The application of EV-based therapy to combat inflammation, though still in an early stage of development, has profound transformative potential. In this review, we highlight the recent progress in EV engineering for inflammation targeting and modulation, summarize their preclinical applications in the treatment of inflammatory disorders, and present our views on the anti-inflammatory applications of EV-based nanotherapeutics.
ISSN:1838-7640
1838-7640
DOI:10.7150/thno.47865