Cryosurgical ablation for treatment of rhinitis: A prospective multicenter study

Objective To assess the efficacy and safety of cryoablation of the posterior nasal nerve (PNN) for treatment of chronic rhinitis. Methods This was a prospective single‐arm trial of 98 adult patients at six U.S. centers with chronic allergic and nonallergic rhinitis. PNN cryoablation was performed in...

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Bibliographic Details
Published in:The Laryngoscope 2020-08, Vol.130 (8), p.1877-1884
Main Authors: Chang, Michael T., Song, Sunhee, Hwang, Peter H.
Format: Article
Language:English
Subjects:
Ablation
Allergies
Allergy, Rhinology, and Immunology
congestion
cryoablation
cryosurgery
Nose
posterior nasal nerve
Quality of life
Rhinitis
rhinorrhea
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Summary:Objective To assess the efficacy and safety of cryoablation of the posterior nasal nerve (PNN) for treatment of chronic rhinitis. Methods This was a prospective single‐arm trial of 98 adult patients at six U.S. centers with chronic allergic and nonallergic rhinitis. PNN cryoablation was performed in‐office under local anesthesia using a handheld device. Patients discontinued use of intranasal ipratropium 3 days prior to treatment and throughout the study period. Reflective Total Nasal Symptom Score (rTNSS) was measured at pretreatment baseline and posttreatment at 1 month, 3 months, 6 months, and 9 months. The Rhinoconjunctivitis Quality of Life Questionnaire (RQLQ) was completed at pretreatment and 3 months posttreatment. Adverse effects and postprocedure medication usage were recorded. Results Ninety‐eight procedures (100%) were successfully completed. rTNSS significantly improved over pretreatment baseline (6.1 ± 1.9) at 1 month (2.9 ± 1.9, P 
ISSN:0023-852X
1531-4995
DOI:10.1002/lary.28301