Interventions for post-stroke fatigue

Post-stroke fatigue (PSF) is a common and distressing problem after stroke. The best ways to prevent or treat PSF are uncertain. Several different interventions can be argued to have a rational basis. To determine whether, among people with stroke, any intervention reduces the proportion of people w...

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Bibliographic Details
Published in:Cochrane database of systematic reviews 2015-07, Vol.2015 (7), p.CD007030-CD007030
Main Authors: Wu, Simiao, Kutlubaev, Mansur A, Chun, Ho-Yan Y, Cowey, Eileen, Pollock, Alex, Macleod, Malcolm R, Dennis, Martin, Keane, Elizabeth, Sharpe, Michael, Mead, Gillian E
Format: Article
Language:English
Subjects:
Antidepressive Agents - therapeutic use
Drugs, Chinese Herbal - therapeutic use
Fatigue - etiology
Fatigue - therapy
Female
Heart & circulation
Humans
Male
Mindfulness - methods
Neurology
PREVENTION AND TREATMENT OF COMPLICATIONS FOLLOWING STROKE
Randomized Controlled Trials as Topic
Stress, Psychological - prevention & control
Stroke - complications
Stroke - psychology
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Summary:Post-stroke fatigue (PSF) is a common and distressing problem after stroke. The best ways to prevent or treat PSF are uncertain. Several different interventions can be argued to have a rational basis. To determine whether, among people with stroke, any intervention reduces the proportion of people with fatigue, fatigue severity, or both; and to determine the effect of intervention on health-related quality of life, disability, dependency and death, and whether such intervention is cost effective. We searched the Cochrane Stroke Group Trials Register (last searched May 2014), Cochrane Central Register of Controlled Trials (The Cochrane Library, 2014, Issue 4), MEDLINE (1950 to May 2014), EMBASE (1980 to May 2014), CINAHL (1982 to May 2014), AMED (1985 to May 2014), PsycINFO (1967 to May 2014), Digital Dissertations (1861 to May 2014), British Nursing Index (1985 to May 2014), PEDro (searched May 2014) and PsycBITE (searched May 2014). We also searched four ongoing trials registries, scanned reference lists, performed citation tracking of included trials and contacted experts. Two review authors independently scrutinised all titles and abstracts and excluded obviously irrelevant studies. We obtained the full texts for potentially relevant studies and three review authors independently applied the inclusion criteria. We included randomised controlled trials (RCTs) that compared an intervention with a control, or compared different interventions for PSF. Two review authors independently extracted data and assessed risk of bias for each included trial. The primary outcomes were severity of fatigue, or proportion of people with fatigue after treatment. We performed separate analyses for trials investigating efficacy in treating PSF, trials investigating efficacy in preventing PSF and trials not primarily investigating efficacy in PSF but which reported fatigue as an outcome. We pooled results from trials that had a control arm. For trials that compared different potentially active interventions without a control arm, we performed analyses for individual trials without pooling.We calculated standardised mean difference (SMD) as the effect size for continuous outcomes and risk ratio (RR) for dichotomous outcomes. We pooled the results using a random-effects model and assessed heterogeneity using the I(2) statistic. We performed separate subgroup analyses for pharmacological and non-pharmacological interventions. We also performed sensitivity analyses to assess the
ISSN:1469-493X
DOI:10.1002/14651858.CD007030.pub3