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Elevated troponin levels are associated with early neurological worsening in ischemic stroke with atrial fibrillation

Serum cardiac troponin I (cTnI) is often elevated in patients with ischemic stroke, and is associated with their prognosis. Since cTnI is also closely related to atrial fibrillation (AF), cTnI may be a sensitive prognostic indicator in patients with AF-related stroke. This study aimed to evaluate th...

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Published in:Scientific reports 2020-07, Vol.10 (1), p.12626-12626, Article 12626
Main Authors: Nam, Ki-Woong, Kim, Chi Kyung, Yu, Sungwook, Chung, Jong-Won, Bang, Oh Young, Kim, Gyeong-Moon, Jung, Jin-Man, Song, Tae-Jin, Kim, Yong-Jae, Kim, Bum Joon, Heo, Sung Hyuk, Park, Kwang-Yeol, Kim, Jeong-Min, Park, Jong-Ho, Choi, Jay Chol, Park, Man-Seok, Kim, Joon-Tae, Choi, Kang-Ho, Hwang, Yang Ha, Seo, Woo-Keun, Oh, Kyungmi
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Language:English
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Summary:Serum cardiac troponin I (cTnI) is often elevated in patients with ischemic stroke, and is associated with their prognosis. Since cTnI is also closely related to atrial fibrillation (AF), cTnI may be a sensitive prognostic indicator in patients with AF-related stroke. This study aimed to evaluate the association between serum cTnI and early neurological deterioration (END) in patients with AF-related stroke. We included consecutive AF-related stroke patients between 2013 and 2015. END was defined as an increase ≥ 2 in the total NIHSS score or ≥ 1 in the motor NIHSS score within the first 72 h of admission. A total of 1,133 patients with AF-related stroke were evaluated. In multivariable analysis, cTnI [adjusted odds ratio (aOR) = 1.16, 95% confidence interval (CI) 1.00–1.34; P  = 0.047] remained significant after adjusting for confounders. Initial NIHSS score (aOR = 1.03, 95% CI 1.00–1.06; P  = 0.043) was also positively associated with END; meanwhile, the use of anticoagulants was negatively associated in both vitamin K antagonists (aOR = 0.35, 95% CI 0.23–0.54; P  
ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-020-69303-5