The Relationship between Prevention and Treatment of Colorectal Cancer and Cancerous Toxin Pathogenesis Theory Basing on Gut Microbiota

Gut microbiota is a diverse consortium of bacteria, fungi, protozoa, and viruses in the gut of all mammals. Gut microbiota remains in steady state under normal conditions. Changes in the internal and external environment may cause gut Microbiota to be out of tune. Malignant tumors are one of the maj...

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Bibliographic Details
Published in:Evidence-based complementary and alternative medicine 2020, Vol.2020 (2020), p.1-9
Main Authors: Chen, Haibin, Zhou, Hongli, Li, Wenting, Qiu, Wenli, Sang, Tianqing, Zhou, Hongguang
Format: Article
Language:English
Subjects:
Apoptosis
Bacteria
Cancer
Cancer therapies
Care and treatment
Chemotherapy
China
Chinese medicine
Clinical medicine
Colon cancer
Colorectal cancer
Colorectal carcinoma
Development and progression
Disease hot spots
Fungi
Gene expression
Health aspects
Herbal medicine
Immunotherapy
Intestinal microflora
Metabolism
Metabolites
Microbiota
Microbiota (Symbiotic organisms)
Morbidity
Mortality
Pathogenesis
Prevention
Probiotics
Protozoa
Review
Small intestine
Theory
Tumors
Type 2 diabetes
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Summary:Gut microbiota is a diverse consortium of bacteria, fungi, protozoa, and viruses in the gut of all mammals. Gut microbiota remains in steady state under normal conditions. Changes in the internal and external environment may cause gut Microbiota to be out of tune. Malignant tumors are one of the major diseases currently endangering human health. CRC (colorectal cancer) has a significant upward trend in morbidity and mortality in many parts of the world. Technological advances have not yet brought about a breakthrough in the efficacy of CRC. The development of colon cancer is closely related to gut microbiota imbalance. According to more than 60 years of clinical practice, Professor Zhongying Zhou first proposed the pathogenesis theory of “cancerous toxin” in the 1990s and believed that cancerous toxin was a key pathogenesis of tumor development. Under the guidance of the theory of cancerous toxin, combined with clinical practice, Professor Zhou created an effective anticancer Chinese herbal compound, Jiedu Xiaoai Prescription. This paper summarizes recent hotspots related to gut microbiota and the occurrence, development, and prevention of colon cancer at home and abroad. The relationship between gut microbiota and cancerous toxin theory is proposed, and the feasibility of further studying the biological basis of cancerous toxin pathogenesis theory from the perspective of gut microbiota is pointed out.
ISSN:1741-427X
1741-4288
DOI:10.1155/2020/7162545