Efficacy of combined orthokeratology and 0.01% atropine solution for slowing axial elongation in children with myopia: a 2-year randomised trial

Eighty Japanese children, aged 8–12 years, with a spherical equivalent refraction (SER) of − 1.00 to − 6.00 dioptres (D) were randomly allocated into two groups to receive either a combination of orthokeratology (OK) and 0.01% atropine solution (combination group) or monotherapy with OK (monotherapy...

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Bibliographic Details
Published in:Scientific reports 2020-07, Vol.10 (1), p.12750, Article 12750
Main Authors: Kinoshita, Nozomi, Konno, Yasuhiro, Hamada, Naoki, Kanda, Yoshinobu, Shimmura-Tomita, Machiko, Kaburaki, Toshikatsu, Kakehashi, Akihiro
Format: Article
Language:English
Subjects:
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Atropine
Atropine - administration & dosage
Axial Length, Eye
Biometry
Child
Children
Elongation
Female
Humanities and Social Sciences
Humans
Japan
Male
multidisciplinary
Myopia
Myopia - drug therapy
Myopia - surgery
Orthokeratologic Procedures
Prospective Studies
Refraction, Ocular
Science
Science (multidisciplinary)
Treatment Outcome
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Summary:Eighty Japanese children, aged 8–12 years, with a spherical equivalent refraction (SER) of − 1.00 to − 6.00 dioptres (D) were randomly allocated into two groups to receive either a combination of orthokeratology (OK) and 0.01% atropine solution (combination group) or monotherapy with OK (monotherapy group). Seventy-three subjects completed the 2-year study. Over the 2 years, axial length increased by 0.29 ± 0.20 mm ( n  = 38) and 0.40 ± 0.23 mm ( n  = 35) in the combination and monotherapy groups, respectively ( P  = 0.03). Interactions between combination treatment and age or SER did not reach significance level (age, P  = 0.18; SER, P  = 0.06). In the subgroup of subjects with an initial SER of − 1.00 to − 3.00 D, axial length increased by 0.30 ± 0.22 mm ( n  = 27) and 0.48 ± 0.22 mm ( n  = 23) in the combination and monotherapy groups, respectively ( P  = 0.005). In the − 3.01 to − 6.00 D subgroup, axial length increased by 0.27 ± 0.15 mm ( n  = 11) and 0.25 ± 0.17 mm ( n  = 12) in the combination and monotherapy groups, respectively ( P  = 0.74). The combination therapy may be effective for slowing axial elongation, especially in children with low initial myopia.
ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-020-69710-8