Current trends in polymer microneedle for transdermal drug delivery

Polymer microneedle promotes the delivery of chemical and biological drugs through the skin. [Display omitted] •Microneedles technology has grown in the last 15 years significantly.•MNs are designed for self-administration by patients with ease.•MNs are of 5 different types: solid, hollow, coated, d...

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Bibliographic Details
Published in:International journal of pharmaceutics 2020-09, Vol.587, p.119673-119673, Article 119673
Main Authors: Ahmed Saeed AL-Japairai, Khater, Mahmood, Syed, Hamed Almurisi, Samah, Reddy Venugopal, Jayarama, Rebhi Hilles, Ayah, Azmana, Motia, Raman, Subashini
Format: Article
Language:English
Subjects:
Administration, Cutaneous
Drug delivery
Drug Delivery Systems
Humans
Microinjections
Microneedle
Needles
Pharmaceutical Preparations
Polymeric needles
Polymers
Skin
Transdermal route
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Summary:Polymer microneedle promotes the delivery of chemical and biological drugs through the skin. [Display omitted] •Microneedles technology has grown in the last 15 years significantly.•MNs are designed for self-administration by patients with ease.•MNs are of 5 different types: solid, hollow, coated, dissolving and hydrogel based.•Polymeric microneedle for delivering of biotherapeutics and small molecules. Transdermal drug delivery using microneedles is increasingly gaining interest due to the issues associated with oral drug delivery routes. Gastrointestinal route exposes the drug to acid and enzymes present in the stomach, leading to denaturation of the compound and resulting in poor bioavailability. Microneedle transdermal drug delivery addresses the problems linked to oral delivery and to relieves the discomfort of patients associated with injections to increase patient compliance. Microneedles can be broadly classified into five types: solid microneedles, coated microneedles, dissolving microneedles, hollow microneedles, and hydrogel-forming microneedles. The materials used for the preparation of microneedles dictate the different applications and features present in the microneedle. Polymeric microneedle arrays present an improved method for transdermal administration of drugs as they penetrate the skin stratum corneum barrier with minimal invasiveness. The review summarizes the importance of polymeric microneedle and discussed some of the most important therapeutic drugs in research, mainly protein drugs, vaccines and small molecule drugs in regenerative medicine.
ISSN:0378-5173
1873-3476
DOI:10.1016/j.ijpharm.2020.119673