A review of the main histopathological findings in coronavirus disease 2019

Coronavirus disease 2019 (COVID-19), caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus, has been declared by the World Health Organization as an emerging public health problem of global importance and classified as a pandemic. SARS-CoV-2 infection can result in diverse...

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Bibliographic Details
Published in:Human pathology 2020-11, Vol.105, p.74-83
Main Authors: Vasquez-Bonilla, Walter O., Orozco, Roberto, Argueta, Víctor, Sierra, Manuel, Zambrano, Lysien I., Muñoz-Lara, Fausto, López-Molina, Dennis Salomón, Arteaga-Livias, Kovy, Grimes, Zachary, Bryce, Clare, Paniz-Mondolfi, Alberto, Rodríguez-Morales, Alfonso J.
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Autopsy
Biopsy
Blood Vessels - pathology
Central Nervous System - pathology
Coronaviruses
COVID-19
COVID-19 - pathology
Female
Histopathology
Humans
Kidney - pathology
Lung - pathology
Lymph Nodes - pathology
Male
Middle Aged
Middle East respiratory syndrome
Myocardium - pathology
Pathology
Respiratory diseases
SARS-CoV-2
Thromboembolism - pathology
Viruses
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Summary:Coronavirus disease 2019 (COVID-19), caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus, has been declared by the World Health Organization as an emerging public health problem of global importance and classified as a pandemic. SARS-CoV-2 infection can result in diverse, multiorgan pathology, the most significant being in the lungs (diffuse alveolar damage in its different phases, microthrombi, bronchopneumonia, necrotizing bronchiolitis, viral pneumonia), heart (lymphocytic myocarditis), kidney (acute tubular injury), central nervous system (microthrombi, ischemic necrosis, acute hemorrhagic infarction, congestion, and vascular edema), lymph nodes (hemophagocytosis and histiocytosis), bone marrow (hemophagocytosis), and vasculature (deep vein thrombosis). An understanding of the spectrum and frequency of histologic findings in COVID-19 is essential for gaining a better understanding of disease pathophysiology and its ongoing impact on public health. To this end, we conducted a systematic meta-analysis of histopathologic observations to date and review the reported findings.
ISSN:0046-8177
1532-8392
DOI:10.1016/j.humpath.2020.07.023