The Chicken as a Model Organism to Study Heart Development

Heart development is a complex process and begins with the long-range migration of cardiac progenitor cells during gastrulation. This culminates in the formation of a simple contractile tube with multiple layers, which undergoes remodeling into a four-chambered heart. During this morphogenesis, addi...

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Bibliographic Details
Published in:Cold Spring Harbor perspectives in biology 2020-08, Vol.12 (8), p.a037218
Main Authors: Wittig, Johannes G, Münsterberg, Andrea
Format: Article
Language:English
Subjects:
Animals
Cell Culture Techniques
Cell Differentiation
Cell Lineage
Cell migration
Cell Movement
Cells (biology)
Cells, Cultured
Chick Embryo
Chickens
Chickens - physiology
Congenital defects
Developmental stages
Embryos
Evolutionary conservation
Fluorescent Dyes
Gastrulation
Heart
Heart - embryology
Heart Defects, Congenital - embryology
Heart Ventricles - embryology
Humans
Life expectancy
Life span
Models, Animal
Morphogenesis
Muscle contraction
Neural Crest - embryology
Organogenesis
Pericardium - embryology
Poultry
Progenitor cells
Quail - embryology
Quail - physiology
Stem cells
TECHNIQUES
Transgenes
Vertebrates
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Summary:Heart development is a complex process and begins with the long-range migration of cardiac progenitor cells during gastrulation. This culminates in the formation of a simple contractile tube with multiple layers, which undergoes remodeling into a four-chambered heart. During this morphogenesis, additional cell populations become incorporated. It is important to unravel the underlying genetic and cellular mechanisms to be able to identify the embryonic origin of diseases, including congenital malformations, which impair cardiac function and may affect life expectancy or quality. Owing to the evolutionary conservation of development, observations made in nonamniote and amniote vertebrate species allow us to extrapolate to human. This review will focus on the contributions made to a better understanding of heart development through studying avian embryos-mainly the chicken but also quail embryos. We will illustrate the classic and recent approaches used in the avian system, give an overview of the important discoveries made, and summarize the early stages of cardiac development up to the establishment of the four-chambered heart.
ISSN:1943-0264
1943-0264
DOI:10.1101/cshperspect.a037218