Metabolic Role of PTEN in Insulin Signaling and Resistance

Phosphatase and tensin homolog (PTEN) is most prominently known for its function in tumorigenesis. However, a metabolic role of PTEN is emerging as a result of its altered expression in type 2 diabetes (T2D), which results in impaired insulin signaling and promotion of insulin resistance during the...

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Bibliographic Details
Published in:Cold Spring Harbor perspectives in medicine 2020-08, Vol.10 (8), p.a036137
Main Authors: Li, Yu Zhe, Di Cristofano, Antonio, Woo, Minna
Format: Article
Language:English
Subjects:
Adipose Tissue - metabolism
Animals
Diabetes Mellitus, Type 2 - genetics
Diabetes Mellitus, Type 2 - metabolism
Humans
Insulin - metabolism
Mice
Mice, Knockout
Muscle, Skeletal - metabolism
PTEN Phosphohydrolase - metabolism
Signal Transduction
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Summary:Phosphatase and tensin homolog (PTEN) is most prominently known for its function in tumorigenesis. However, a metabolic role of PTEN is emerging as a result of its altered expression in type 2 diabetes (T2D), which results in impaired insulin signaling and promotion of insulin resistance during the pathogenesis of T2D. PTEN functions in regulating insulin signaling across different organs have been identified. Through the use of a variety of models, such as tissue-specific knockout (KO) mice and in vitro cell cultures, PTEN's role in regulating insulin action has been elucidated across many cell types. Herein, we will review the recent advancements in the understanding of PTEN's metabolic functions in each of the tissues and cell types that contribute to regulating systemic insulin sensitivity and discuss how PTEN may represent a promising therapeutic strategy for treatment or prevention of T2D.
ISSN:2157-1422
2472-5412
DOI:10.1101/cshperspect.a036137