Interleukin-19 enhances cytokine production induced by lipopolysaccharide and inhibits cytokine production induced by polyI:C in BALB/c mice

Interleukin (IL)-19 is a cytokine of the IL-10 family. There are many reports on the involvement of IL-19 in several human diseases. There also are many reports elucidating the role of IL-19 using mouse disease models. Most reports use C57BL/6 mice, whereas few reports use BALB/c mice, in terms of t...

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Bibliographic Details
Published in:Journal of Veterinary Medical Science 2020, Vol.82(7), pp.891-896
Main Authors: AZUMA, Yasu-Taka, NISHIYAMA, Kazuhiro
Format: Article
Language:English
Subjects:
Animal models
Animals
Bacterial infections
BALB/c mouse
Cytokines
Cytokines - blood
Cytokines - metabolism
Disease Models, Animal
Experiments
Interleukin 10
Interleukin 19
Interleukins - genetics
Interleukins - metabolism
lipopolysaccharide
Lipopolysaccharides
Lipopolysaccharides - pharmacology
Male
Mice, Inbred BALB C
Mice, Knockout
Oligodeoxyribonucleotides - pharmacology
Pharmacology
Poly (I:C)
Poly I-C - pharmacology
polyI:C
Rodents
serum
Viral infections
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Summary:Interleukin (IL)-19 is a cytokine of the IL-10 family. There are many reports on the involvement of IL-19 in several human diseases. There also are many reports elucidating the role of IL-19 using mouse disease models. Most reports use C57BL/6 mice, whereas few reports use BALB/c mice, in terms of the mouse disease model that the researchers used in the present study. To date, research on the role of IL-19 is diversified, yet some basic mechanisms are still unclear. In this study, we administered lipopolysaccharide (LPS), polyI:C, and CpG to BALB/c mice, measured more than 20 cytokines in the blood and compared them with that of the wild-type and IL-19-deficient (IL-19 KO) mice. LPS is associated with bacterial infection, polyI:C is associated with viral infection, and CpG is associated with both bacterial and viral infections. Among the cytokines measured, the results of experiments using LPS revealed that the production of some cytokines was suppressed in IL-19 KO mice. Interestingly, the experiments using polyI:C revealed that production of some cytokines was enhanced in IL-19 KO mice. However, the experiments using CpG have shown that the production of only one cytokine was enhanced in IL-19 KO mice. These results revealed that cytokine production in the blood was regulated by IL-19, and the type of regulation was dependent on the administered stimulant.
ISSN:0916-7250
1347-7439
DOI:10.1292/jvms.20-0137