Nanoengineered Light‐Activatable Polybubbles for On‐Demand Therapeutic Delivery

Vaccine coverage is severely limited in developing countries due to inefficient protection of vaccine functionality as well as lack of patient compliance to receive the additional booster doses. Thus, there is an urgent need to design a thermostable vaccine delivery platform that also enables releas...

Full description

Saved in:
Bibliographic Details
Published in:Advanced functional materials 2020-08, Vol.30 (31), p.2003579-n/a
Main Authors: Arun Kumar, Shreedevi, Good, Jacob, Hendrix, David, Yoo, Eunsoo, Kim, Dongin, Deo, Kaivalya A., Jhan, Yong‐Yu, Gaharwar, Akhilesh K., Bishop, Corey J.
Format: Article
Language:English
Subjects:
Activation
Antigens
Cargo
delayed burst
Demand
Developing countries
diffusion
Drug delivery systems
drug depot
In vivo methods and tests
LDCs
light‐activatable polybubbles, nanomaterials
Materials science
Nanorods
Nucleic acids
stimuli responsive materials
Vaccines
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Vaccine coverage is severely limited in developing countries due to inefficient protection of vaccine functionality as well as lack of patient compliance to receive the additional booster doses. Thus, there is an urgent need to design a thermostable vaccine delivery platform that also enables release of the bolus after predetermined time. Here, the formation of injectable and light‐activatable polybubbles for vaccine delivery is reported. In vitro studies show that polybubbles enable delayed burst release, irrespective of cargo types, namely small molecule and antigen. The extracorporeal activation of polybubbles is achieved by incorporating near‐infrared (NIR)‐sensitive gold nanorods (AuNRs). Interestingly, light‐activatable polybubbles can be used for on‐demand burst release of cargo. In vitro, ex vivo, and in vivo studies demonstrate successful activation of AuNR‐loaded polybubbles. Overall, the light‐activatable polybubble technology can be used for on‐demand delivery of various therapeutics including small molecule drugs, immunologically relevant protein, peptide antigens, and nucleic acids. Polybubbles are a novel drug delivery platform to enable differential delayed burst release of a variety of cargo types including small molecules and proteins from a single depot. This technology can be used for vaccine delivery applications. Polybubbles can also enable on‐demand delivery of cargo upon light activation to further regulate cargo release.
ISSN:1616-301X
1616-3028
DOI:10.1002/adfm.202003579