Caudal dexmedetomidine in pediatric caudal anesthesia: A systematic review and meta-analysis of randomized controlled trials

To evaluate the efficacy and safety of caudal dexmedetomidine in pediatric caudal anesthesia (CA). We searched PubMed, Embased, and Cochrane Library (from inception to June 2019) for eligible studies. The primary outcomes were the time to first analgesia, time of postoperative eye opening, intraoper...

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Bibliographic Details
Published in:Medicine (Baltimore) 2020-07, Vol.99 (31), p.e21397-e21397
Main Authors: Wang, Xian-xue, Dai, Jing, Dai, Li, Guo, Hua-jing, Zhou, Ai-guo, Pan, Dao-bo
Format: Article
Language:English
Subjects:
Anesthesia, Caudal
Child
Dexmedetomidine - administration & dosage
Humans
Hypnotics and Sedatives - administration & dosage
Pain, Postoperative - prevention & control
Randomized Controlled Trials as Topic
Systematic Review and Meta-Analysis
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Summary:To evaluate the efficacy and safety of caudal dexmedetomidine in pediatric caudal anesthesia (CA). We searched PubMed, Embased, and Cochrane Library (from inception to June 2019) for eligible studies. The primary outcomes were the time to first analgesia, time of postoperative eye opening, intraoperative endtidal sevoflurane concentration, and postoperative sedation score. We calculated pooled risk ratios (RR) and 95% CIs using random- or fixed-effects models. Thirteen trials involving 793 patients were found. Meta-analysis showed that the time to first rescue pain medication and the time from the end of anesthesia to eye opening in the CA+dexmedetomidine group were significantly longer than in the CA group (P 
ISSN:0025-7974
1536-5964
DOI:10.1097/MD.0000000000021397