Clinical and Radiological Evaluations of COVID‐19 Patients With Anosmia: Preliminary Report

Objectives/Hypothesis To investigate clinical and radiological features of olfactory clefts of patients with mild coronavirus disease 2019 (COVID‐19). Study Design Prospective non controlled study. Methods Sixteen COVID‐19 patients were recruited. The epidemiological and clinical data were extracted...

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Published in:The Laryngoscope 2020-11, Vol.130 (11), p.2526-2531
Main Authors: Lechien, Jerome R., Michel, Justin, Radulesco, Thomas, Chiesa‐Estomba, Carlos M., Vaira, Luigi A., De Riu, Giacomo, Sowerby, Leigh, Hopkins, Claire, Saussez, Sven
Format: Article
Language:English
Subjects:
Adult
Allergy, Rhinology, and Immunology
anosmia
Anosmia - diagnostic imaging
Anosmia - pathology
Anosmia - virology
computed tomography scan
coronavirus
COVID-19
COVID-19 - complications
COVID-19 - diagnostic imaging
COVID-19 - pathology
Endoscopy
evaluation
Female
Humans
imaging
Life Sciences
Male
Middle Aged
olfaction
Olfaction disorders
Olfaction Disorders - diagnostic imaging
Olfaction Disorders - pathology
Olfaction Disorders - virology
olfactory
Prospective Studies
SARS-CoV-2
Sensory perception
Smell
taste
Tomography, X-Ray Computed
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Summary:Objectives/Hypothesis To investigate clinical and radiological features of olfactory clefts of patients with mild coronavirus disease 2019 (COVID‐19). Study Design Prospective non controlled study. Methods Sixteen COVID‐19 patients were recruited. The epidemiological and clinical data were extracted. Nasal complaints were assessed through the 22‐item Sino‐Nasal Outcome Test. Patients underwent psychophysical olfactory testing, olfactory cleft examination, and computed tomography (CT) scans. Results Sixteen anosmic patients were included. The mean Sniffin' Sticks score was 4.6 ± 1.7. The majority of patients had no endoscopical abnormality, with a mean olfactory cleft endoscopy score of 0.6 ± 0.9. The olfactory clefts were opacified in three patients on the CT scan. The mean radiological olfactory cleft score was 0.7 ± 0.8. There were no significant correlations between clinical, radiological, and psychophysical olfactory testing. Conclusions The olfactory cleft of anosmic COVID‐19 patients is free regarding endoscopic examination and imaging. The anosmia etiology is not related to edema of the olfactory cleft. Level of Evidence 4 Laryngoscope, 130:2526–2531, 2020
ISSN:0023-852X
1531-4995
DOI:10.1002/lary.28993