SARS‐CoV‐2 diagnostics in the virology laboratory of a University Hospital in Rome during the lockdown period

Italy was one of the most affected nations by coronavirus disease 2019 outside China. The infections, initially limited to Northern Italy, spread to all other Italian regions. This study aims to provide a snapshot of severe acute respiratory syndrome coronavirus‐2 (SARS‐CoV‐2) epidemiology based on...

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Bibliographic Details
Published in:Journal of Medical Virology 2021-02, Vol.93 (2), p.886-891
Main Authors: Turriziani, Ombretta, Sciandra, Ilaria, Mazzuti, Laura, Di Carlo, Daniele, Bitossi, Camilla, Calabretto, Marianna, Guerrizio, Giuliana, Oliveto, Giuseppe, Riveros Cabral, Rodolfo J., Viscido, Agnese, Falasca, Francesca, Gentile, Massimo, Pietropaolo, Valeria, Rodio, Donatella M., Carattoli, Alessandra, Antonelli, Guido
Format: Article
Language:English
Subjects:
Adolescent
Adult
Age
Aged
Aged, 80 and over
Alveoli
Bronchoalveolar Lavage Fluid - virology
Bronchus
Cerebrospinal fluid
Child
Child, Preschool
Coronaviridae
Coronaviruses
COVID-19
COVID-19 - diagnosis
COVID-19 - epidemiology
COVID-19 Testing
Epidemiology
Feces - virology
Female
Gender
Hospitals, University
Humans
Infant
Infant, Newborn
Infections
Laboratories
laboratory diagnostics
Lavage
Lethality
Male
Middle Aged
Nasopharynx - virology
Pandemics
Pleural Effusion - virology
Respiratory diseases
Retrospective Studies
Reverse Transcriptase Polymerase Chain Reaction
Rome - epidemiology
SARS-CoV-2 - genetics
SARS-CoV-2 - pathogenicity
SARS‐CoV‐2
Severe acute respiratory syndrome
Severe acute respiratory syndrome coronavirus 2
Severity of Illness Index
Viral diseases
Virology
Viruses
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Summary:Italy was one of the most affected nations by coronavirus disease 2019 outside China. The infections, initially limited to Northern Italy, spread to all other Italian regions. This study aims to provide a snapshot of severe acute respiratory syndrome coronavirus‐2 (SARS‐CoV‐2) epidemiology based on a single‐center laboratory experience in Rome. The study retrospectively included 6565 subjects tested for SARS‐CoV‐2 at the Laboratory of Virology of Sapienza University Hospital in Rome from 6 March to 4 May. A total of 9995 clinical specimens were analyzed, including nasopharyngeal swabs, bronchoalveolar lavage fluids, gargle lavages, stools, pleural fluids, and cerebrospinal fluids. Positivity to SARS‐CoV‐2 was detected in 8% (527/6565) of individuals, increased with age, and was higher in male patients (P  
ISSN:0146-6615
1096-9071
DOI:10.1002/jmv.26332