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SARS‐CoV‐2 diagnostics in the virology laboratory of a University Hospital in Rome during the lockdown period
Italy was one of the most affected nations by coronavirus disease 2019 outside China. The infections, initially limited to Northern Italy, spread to all other Italian regions. This study aims to provide a snapshot of severe acute respiratory syndrome coronavirus‐2 (SARS‐CoV‐2) epidemiology based on...
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| Published in: | Journal of Medical Virology 2021-02, Vol.93 (2), p.886-891 |
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| cites | cdi_FETCH-LOGICAL-c4712-3628cd1fe2320e508faef310a197e00c8e0ca4ab4ebd7798b95872139f66b2a13 |
| container_end_page | 891 |
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| container_title | Journal of Medical Virology |
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| creator | Turriziani, Ombretta Sciandra, Ilaria Mazzuti, Laura Di Carlo, Daniele Bitossi, Camilla Calabretto, Marianna Guerrizio, Giuliana Oliveto, Giuseppe Riveros Cabral, Rodolfo J. Viscido, Agnese Falasca, Francesca Gentile, Massimo Pietropaolo, Valeria Rodio, Donatella M. Carattoli, Alessandra Antonelli, Guido |
| description | Italy was one of the most affected nations by coronavirus disease 2019 outside China. The infections, initially limited to Northern Italy, spread to all other Italian regions. This study aims to provide a snapshot of severe acute respiratory syndrome coronavirus‐2 (SARS‐CoV‐2) epidemiology based on a single‐center laboratory experience in Rome. The study retrospectively included 6565 subjects tested for SARS‐CoV‐2 at the Laboratory of Virology of Sapienza University Hospital in Rome from 6 March to 4 May. A total of 9995 clinical specimens were analyzed, including nasopharyngeal swabs, bronchoalveolar lavage fluids, gargle lavages, stools, pleural fluids, and cerebrospinal fluids. Positivity to SARS‐CoV‐2 was detected in 8% (527/6565) of individuals, increased with age, and was higher in male patients (P |
| doi_str_mv | 10.1002/jmv.26332 |
| format | article |
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Highlights
This is the first study reporting an epidemiological insight for the SARS‐CoV‐2 infection in Rome.
The containing measures have been effective to flatten epidemiological curve.
Gender and age are important contributor to lethality.</description><identifier>ISSN: 0146-6615</identifier><identifier>EISSN: 1096-9071</identifier><identifier>DOI: 10.1002/jmv.26332</identifier><identifier>PMID: 32697357</identifier><language>eng</language><publisher>United States: John Wiley & Sons, Inc</publisher><subject>Adolescent ; Adult ; Age ; Aged ; Aged, 80 and over ; Alveoli ; Bronchoalveolar Lavage Fluid - virology ; Bronchus ; Cerebrospinal fluid ; Child ; Child, Preschool ; Coronaviridae ; Coronaviruses ; COVID-19 ; COVID-19 - diagnosis ; COVID-19 - epidemiology ; COVID-19 Testing ; Epidemiology ; Feces - virology ; Female ; Gender ; Hospitals, University ; Humans ; Infant ; Infant, Newborn ; Infections ; Laboratories ; laboratory diagnostics ; Lavage ; Lethality ; Male ; Middle Aged ; Nasopharynx - virology ; Pandemics ; Pleural Effusion - virology ; Respiratory diseases ; Retrospective Studies ; Reverse Transcriptase Polymerase Chain Reaction ; Rome - epidemiology ; SARS-CoV-2 - genetics ; SARS-CoV-2 - pathogenicity ; SARS‐CoV‐2 ; Severe acute respiratory syndrome ; Severe acute respiratory syndrome coronavirus 2 ; Severity of Illness Index ; Viral diseases ; Virology ; Viruses</subject><ispartof>Journal of Medical Virology, 2021-02, Vol.93 (2), p.886-891</ispartof><rights>2020 Wiley Periodicals LLC</rights><rights>2020 Wiley Periodicals LLC.</rights><rights>2020. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the associated terms available at https://novel-coronavirus.onlinelibrary.wiley.com</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4712-3628cd1fe2320e508faef310a197e00c8e0ca4ab4ebd7798b95872139f66b2a13</citedby><cites>FETCH-LOGICAL-c4712-3628cd1fe2320e508faef310a197e00c8e0ca4ab4ebd7798b95872139f66b2a13</cites><orcidid>0000-0002-2533-2939 ; 0000-0001-6400-9168 ; 0000-0002-6120-6526</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.proquest.com/docview/2426063676?pq-origsite=primo$$EHTML$$P50$$Gproquest$$H</linktohtml><link.rule.ids>230,314,780,784,885,27924,27925,38516,43895</link.rule.ids><linktorsrc>$$Uhttps://www.proquest.com/docview/2426063676?pq-origsite=primo$$EView_record_in_ProQuest$$FView_record_in_$$GProQuest</linktorsrc><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32697357$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Turriziani, Ombretta</creatorcontrib><creatorcontrib>Sciandra, Ilaria</creatorcontrib><creatorcontrib>Mazzuti, Laura</creatorcontrib><creatorcontrib>Di Carlo, Daniele</creatorcontrib><creatorcontrib>Bitossi, Camilla</creatorcontrib><creatorcontrib>Calabretto, Marianna</creatorcontrib><creatorcontrib>Guerrizio, Giuliana</creatorcontrib><creatorcontrib>Oliveto, Giuseppe</creatorcontrib><creatorcontrib>Riveros Cabral, Rodolfo J.</creatorcontrib><creatorcontrib>Viscido, Agnese</creatorcontrib><creatorcontrib>Falasca, Francesca</creatorcontrib><creatorcontrib>Gentile, Massimo</creatorcontrib><creatorcontrib>Pietropaolo, Valeria</creatorcontrib><creatorcontrib>Rodio, Donatella M.</creatorcontrib><creatorcontrib>Carattoli, Alessandra</creatorcontrib><creatorcontrib>Antonelli, Guido</creatorcontrib><title>SARS‐CoV‐2 diagnostics in the virology laboratory of a University Hospital in Rome during the lockdown period</title><title>Journal of Medical Virology</title><addtitle>J Med Virol</addtitle><description>Italy was one of the most affected nations by coronavirus disease 2019 outside China. The infections, initially limited to Northern Italy, spread to all other Italian regions. This study aims to provide a snapshot of severe acute respiratory syndrome coronavirus‐2 (SARS‐CoV‐2) epidemiology based on a single‐center laboratory experience in Rome. The study retrospectively included 6565 subjects tested for SARS‐CoV‐2 at the Laboratory of Virology of Sapienza University Hospital in Rome from 6 March to 4 May. A total of 9995 clinical specimens were analyzed, including nasopharyngeal swabs, bronchoalveolar lavage fluids, gargle lavages, stools, pleural fluids, and cerebrospinal fluids. Positivity to SARS‐CoV‐2 was detected in 8% (527/6565) of individuals, increased with age, and was higher in male patients (P < .001). The number of new confirmed cases reached a peak on 18 March and then decreased. The virus was detected in respiratory samples, in stool and in pleural fluids, while none of gargle lavage or cerebrospinal fluid samples gave a positive result. This analysis allowed to gather comprehensive information on SARS‐CoV‐2 epidemiology in our area, highlighting positivity variations over time and in different sex and age group and the need for a continuous surveillance of the infection, mostly because the pandemic evolution remains unknown.
Highlights
This is the first study reporting an epidemiological insight for the SARS‐CoV‐2 infection in Rome.
The containing measures have been effective to flatten epidemiological curve.
Gender and age are important contributor to lethality.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Age</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Alveoli</subject><subject>Bronchoalveolar Lavage Fluid - virology</subject><subject>Bronchus</subject><subject>Cerebrospinal fluid</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Coronaviridae</subject><subject>Coronaviruses</subject><subject>COVID-19</subject><subject>COVID-19 - diagnosis</subject><subject>COVID-19 - epidemiology</subject><subject>COVID-19 Testing</subject><subject>Epidemiology</subject><subject>Feces - virology</subject><subject>Female</subject><subject>Gender</subject><subject>Hospitals, University</subject><subject>Humans</subject><subject>Infant</subject><subject>Infant, Newborn</subject><subject>Infections</subject><subject>Laboratories</subject><subject>laboratory diagnostics</subject><subject>Lavage</subject><subject>Lethality</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Nasopharynx - virology</subject><subject>Pandemics</subject><subject>Pleural Effusion - virology</subject><subject>Respiratory diseases</subject><subject>Retrospective Studies</subject><subject>Reverse Transcriptase Polymerase Chain Reaction</subject><subject>Rome - epidemiology</subject><subject>SARS-CoV-2 - genetics</subject><subject>SARS-CoV-2 - pathogenicity</subject><subject>SARS‐CoV‐2</subject><subject>Severe acute respiratory syndrome</subject><subject>Severe acute respiratory syndrome coronavirus 2</subject><subject>Severity of Illness Index</subject><subject>Viral diseases</subject><subject>Virology</subject><subject>Viruses</subject><issn>0146-6615</issn><issn>1096-9071</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>COVID</sourceid><recordid>eNp9kcFu1DAQhi1ERbeFAy-ALHGBQ9qxndjxBalaAW1VhNTSXi0ncbZeHHtrJ1vl1kfgGXkSst22AiS4jA_zzTce_Qi9JnBAAOjhslsfUM4YfYZmBCTPJAjyHM2A5DzjnBS7aC-lJQCUktIXaJdRLgUrxAzdXBydX_y8-zEPV1OluLF64UPqbZ2w9bi_NnhtY3BhMWKnqxB1H-KIQ4s1vvR2bWKy_YiPQ1rZXrvNzHnoDG6GaP3ift6F-nsTbj1emWhD8xLttNol8-rh3UeXnz5-mx9nZ18_n8yPzrI6F4RmjNOybkhrKKNgCihbbVpGQBMpDEBdGqh1rqvcVI0QsqxkUQpKmGw5r6gmbB992HpXQ9WZpja-j9qpVbSdjqMK2qo_O95eq0VYK5FDwSSfBO8eBDHcDCb1qrOpNs5pb8KQFM0pJ4JPZULf_oUuwxD9dN5ECVYCMJn_n6IcOONis_b9lqpjSCma9unLBNQmbjXFre7jntg3v9_4RD7mOwGHW-DWOjP-26ROv1xtlb8Afu62Vg</recordid><startdate>202102</startdate><enddate>202102</enddate><creator>Turriziani, Ombretta</creator><creator>Sciandra, Ilaria</creator><creator>Mazzuti, Laura</creator><creator>Di Carlo, Daniele</creator><creator>Bitossi, Camilla</creator><creator>Calabretto, Marianna</creator><creator>Guerrizio, Giuliana</creator><creator>Oliveto, Giuseppe</creator><creator>Riveros Cabral, Rodolfo J.</creator><creator>Viscido, Agnese</creator><creator>Falasca, Francesca</creator><creator>Gentile, Massimo</creator><creator>Pietropaolo, Valeria</creator><creator>Rodio, Donatella M.</creator><creator>Carattoli, Alessandra</creator><creator>Antonelli, Guido</creator><general>John Wiley & Sons, Inc</general><general>Wiley Subscription Services, Inc</general><general>John Wiley and Sons Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>COVID</scope><scope>7QL</scope><scope>7TK</scope><scope>7U9</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>H94</scope><scope>K9.</scope><scope>M7N</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-2533-2939</orcidid><orcidid>https://orcid.org/0000-0001-6400-9168</orcidid><orcidid>https://orcid.org/0000-0002-6120-6526</orcidid></search><sort><creationdate>202102</creationdate><title>SARS‐CoV‐2 diagnostics in the virology laboratory of a University Hospital in Rome during the lockdown period</title><author>Turriziani, Ombretta ; Sciandra, Ilaria ; Mazzuti, Laura ; Di Carlo, Daniele ; Bitossi, Camilla ; Calabretto, Marianna ; Guerrizio, Giuliana ; Oliveto, Giuseppe ; Riveros Cabral, Rodolfo J. ; Viscido, Agnese ; Falasca, Francesca ; Gentile, Massimo ; Pietropaolo, Valeria ; Rodio, Donatella M. ; Carattoli, Alessandra ; Antonelli, Guido</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4712-3628cd1fe2320e508faef310a197e00c8e0ca4ab4ebd7798b95872139f66b2a13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Age</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Alveoli</topic><topic>Bronchoalveolar Lavage Fluid - 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pathogenicity</topic><topic>SARS‐CoV‐2</topic><topic>Severe acute respiratory syndrome</topic><topic>Severe acute respiratory syndrome coronavirus 2</topic><topic>Severity of Illness Index</topic><topic>Viral diseases</topic><topic>Virology</topic><topic>Viruses</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Turriziani, Ombretta</creatorcontrib><creatorcontrib>Sciandra, Ilaria</creatorcontrib><creatorcontrib>Mazzuti, Laura</creatorcontrib><creatorcontrib>Di Carlo, Daniele</creatorcontrib><creatorcontrib>Bitossi, Camilla</creatorcontrib><creatorcontrib>Calabretto, Marianna</creatorcontrib><creatorcontrib>Guerrizio, Giuliana</creatorcontrib><creatorcontrib>Oliveto, Giuseppe</creatorcontrib><creatorcontrib>Riveros Cabral, Rodolfo J.</creatorcontrib><creatorcontrib>Viscido, Agnese</creatorcontrib><creatorcontrib>Falasca, Francesca</creatorcontrib><creatorcontrib>Gentile, Massimo</creatorcontrib><creatorcontrib>Pietropaolo, Valeria</creatorcontrib><creatorcontrib>Rodio, Donatella M.</creatorcontrib><creatorcontrib>Carattoli, Alessandra</creatorcontrib><creatorcontrib>Antonelli, Guido</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Coronavirus Research Database</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Neurosciences Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Journal of Medical Virology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>Turriziani, Ombretta</au><au>Sciandra, Ilaria</au><au>Mazzuti, Laura</au><au>Di Carlo, Daniele</au><au>Bitossi, Camilla</au><au>Calabretto, Marianna</au><au>Guerrizio, Giuliana</au><au>Oliveto, Giuseppe</au><au>Riveros Cabral, Rodolfo J.</au><au>Viscido, Agnese</au><au>Falasca, Francesca</au><au>Gentile, Massimo</au><au>Pietropaolo, Valeria</au><au>Rodio, Donatella M.</au><au>Carattoli, Alessandra</au><au>Antonelli, Guido</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>SARS‐CoV‐2 diagnostics in the virology laboratory of a University Hospital in Rome during the lockdown period</atitle><jtitle>Journal of Medical Virology</jtitle><addtitle>J Med Virol</addtitle><date>2021-02</date><risdate>2021</risdate><volume>93</volume><issue>2</issue><spage>886</spage><epage>891</epage><pages>886-891</pages><issn>0146-6615</issn><eissn>1096-9071</eissn><abstract>Italy was one of the most affected nations by coronavirus disease 2019 outside China. The infections, initially limited to Northern Italy, spread to all other Italian regions. This study aims to provide a snapshot of severe acute respiratory syndrome coronavirus‐2 (SARS‐CoV‐2) epidemiology based on a single‐center laboratory experience in Rome. The study retrospectively included 6565 subjects tested for SARS‐CoV‐2 at the Laboratory of Virology of Sapienza University Hospital in Rome from 6 March to 4 May. A total of 9995 clinical specimens were analyzed, including nasopharyngeal swabs, bronchoalveolar lavage fluids, gargle lavages, stools, pleural fluids, and cerebrospinal fluids. Positivity to SARS‐CoV‐2 was detected in 8% (527/6565) of individuals, increased with age, and was higher in male patients (P < .001). The number of new confirmed cases reached a peak on 18 March and then decreased. The virus was detected in respiratory samples, in stool and in pleural fluids, while none of gargle lavage or cerebrospinal fluid samples gave a positive result. This analysis allowed to gather comprehensive information on SARS‐CoV‐2 epidemiology in our area, highlighting positivity variations over time and in different sex and age group and the need for a continuous surveillance of the infection, mostly because the pandemic evolution remains unknown.
Highlights
This is the first study reporting an epidemiological insight for the SARS‐CoV‐2 infection in Rome.
The containing measures have been effective to flatten epidemiological curve.
Gender and age are important contributor to lethality.</abstract><cop>United States</cop><pub>John Wiley & Sons, Inc</pub><pmid>32697357</pmid><doi>10.1002/jmv.26332</doi><tpages>6</tpages><orcidid>https://orcid.org/0000-0002-2533-2939</orcidid><orcidid>https://orcid.org/0000-0001-6400-9168</orcidid><orcidid>https://orcid.org/0000-0002-6120-6526</orcidid><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 0146-6615 |
| ispartof | Journal of Medical Virology, 2021-02, Vol.93 (2), p.886-891 |
| issn | 0146-6615 1096-9071 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7405396 |
| source | Coronavirus Research Database |
| subjects | Adolescent Adult Age Aged Aged, 80 and over Alveoli Bronchoalveolar Lavage Fluid - virology Bronchus Cerebrospinal fluid Child Child, Preschool Coronaviridae Coronaviruses COVID-19 COVID-19 - diagnosis COVID-19 - epidemiology COVID-19 Testing Epidemiology Feces - virology Female Gender Hospitals, University Humans Infant Infant, Newborn Infections Laboratories laboratory diagnostics Lavage Lethality Male Middle Aged Nasopharynx - virology Pandemics Pleural Effusion - virology Respiratory diseases Retrospective Studies Reverse Transcriptase Polymerase Chain Reaction Rome - epidemiology SARS-CoV-2 - genetics SARS-CoV-2 - pathogenicity SARS‐CoV‐2 Severe acute respiratory syndrome Severe acute respiratory syndrome coronavirus 2 Severity of Illness Index Viral diseases Virology Viruses |
| title | SARS‐CoV‐2 diagnostics in the virology laboratory of a University Hospital in Rome during the lockdown period |
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